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Changes to membrane potential during development[edit]

A neuron’s resting membrane potential actually changes during the development of an organism. In order for a neuron to eventually adopt its full adult function, its potential must be tightly regulated during development. As an organism progresses through development the resting membrane potential becomes more negative.^[1] Glial cells are also differentiating and proliferating as development progresses in the brain.^[2] The addition of these glial cells increases the organism’s ability to regulate extracellular potassium. The drop in extracellular potassium can lead to a decrease in membrane potential of 35 mV.^[3]

^ Sanes, Dan H.; Takács, Catherine (1993-06-01). "Activity‐dependent Refinement of Inhibitory Connections". European Journal of Neuroscience. 5 (6): 570–574. doi:10.1111/j.1460-9568.1993.tb00522.x. ISSN 1460-9568.
^ KOFUJI, P.; NEWMAN, E. A. (2004-01-01). "POTASSIUM BUFFERING IN THE CENTRAL NERVOUS SYSTEM". Neuroscience. 129 (4): 1045–1056. doi:10.1016/j.neuroscience.2004.06.008. ISSN 0306-4522. PMC 2322935. PMID 15561419.{{cite journal}}: CS1 maint: PMC format (link)
^ Sanes, Dan H.; Reh, Thomas A (2012-01-01). Development of the nervous system (Third Edition). Elsevier Academic Press. p. 211. ISBN 9780080923208. OCLC 762720374.{{cite book}}: CS1 maint: date and year (link)

[1] Sanes, Dan H.; Takács, Catherine (1993-06-01). "Activity‐dependent Refinement of Inhibitory Connections". European Journal of Neuroscience. 5 (6): 570–574. doi:10.1111/j.1460-9568.1993.tb00522.x. ISSN 1460-9568.

[2] KOFUJI, P.; NEWMAN, E. A. (2004-01-01). "POTASSIUM BUFFERING IN THE CENTRAL NERVOUS SYSTEM". Neuroscience. 129 (4): 1045–1056. doi:10.1016/j.neuroscience.2004.06.008. ISSN 0306-4522. PMC 2322935. PMID 15561419.{{cite journal}}: CS1 maint: PMC format (link)

[3] Sanes, Dan H.; Reh, Thomas A (2012-01-01). Development of the nervous system (Third Edition). Elsevier Academic Press. p. 211. ISBN 9780080923208. OCLC 762720374.{{cite book}}: CS1 maint: date and year (link)

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