User:Mr. Ibrahem/Typical antipsychotic
| Mr. Ibrahem/Typical antipsychotic | |
|---|---|
| Drug class | |
| Synonyms | First generation antipsychotics, conventional antipsychotics, classical neuroleptics, traditional antipsychotics, major tranquilizers |
| Legal status | |
Typical antipsychotics are a class of medication of the antipsychotic type.[1] They are primarily used for agitation, schizophrenia, bipolar, and nausea.[2] Other uses may include hiccups.[2] They can be taken by mouth or used by injection.[1] Long acting injectable formulations are also available.[1]
Side effects may include involuntary movement disorders, including tardive dyskinesia, sleepiness, low blood pressure, and sexual dysfunction.[2] Other serious side effects may include neuroleptic malignant syndrome and QT prolongation.[2] They cause less weight gain and diabetes than atypical antipsychotics.[1] In dementia they increase the risk of death.[2] They are believed to work by blocking receptors in the brain for dopamine.[2]
They were first developed in the 1950s with chlorpromazine.[3] They are available as generic medication and are generally relatively inexpensive.[2] Some of the long acting injectable formulations are more expensive.[2]
References[edit]
- ^ a b c d Chokhawala, K; Stevens, L (January 2021). "Antipsychotic Medications". PMID 30137788.
{{cite journal}}: Cite journal requires|journal=(help) - ^ a b c d e f g h Hitchings, Andrew; Lonsdale, Dagan; Burrage, Daniel; Baker, Emma (2019). The Top 100 Drugs: Clinical Pharmacology and Practical Prescribing (2nd ed.). Elsevier. p. 78. ISBN 978-0-7020-7442-4. Archived from the original on 2021-05-22. Retrieved 2021-11-09.
- ^ Shen WW (1999). "A history of antipsychotic drug development". Comprehensive Psychiatry. 40 (6): 407–14. doi:10.1016/s0010-440x(99)90082-2. PMID 10579370.