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User:Mr. Ibrahem/Fostamatinib

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Mr. Ibrahem/Fostamatinib
Clinical data
Trade namesTavalisse, Tavlesse
Other namesFostamatinib disodium hexahydrate, tamatinib fosdium, R-788, NSC-745942, R-935788
AHFS/Drugs.comMonograph
MedlinePlusa618025
License data
Pregnancy
category
  • Not recommended
Routes of
administration		By mouth
Drug classTyrosine kinase inhibitor[1]
Legal status
Legal status
Pharmacokinetic data
Bioavailability55% (tamatinib metabolite)
Protein binding98% (tamatinib metabolite)
MetabolismGut (ALP to tamatinib)
Liver (tamatinib metabolite by CYP3A4, UGT1A9)
Elimination half-life15 hours
Excretionfaecal (80%), urine (20%)
Identifiers
  • [6-({5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl}amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate
Chemical and physical data
FormulaC23H26FN6O9P
Molar mass580.466 g·mol−1
3D model (JSmol)
  • Fc1cnc(nc1Nc2nc3N(C(=O)C(Oc3cc2)(C)C)COP(=O)(O)O)Nc4cc(OC)c(OC)c(OC)c4
  • InChI=1S/C23H26FN6O9P/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29) checkY

Fostamatinib, sold under the brand names Tavalisse and Tavlesse, is a medication used to treat chronic immune thrombocytopenia (ITP).[2][3] It is used in cases were other medications have not worked.[2] It is taken by mouth.[2]

Common side effects include diarrhea, high blood pressure, nausea, respiratory infection, dizziness, liver problems, rash, abdominal pain, tiredness, chest pain, and low white blood cells.[2] Use in pregnancy may harm the baby.[2] It is a tyrosine kinase inhibitor which blocks the enzyme spleen tyrosine kinase (SYK).[3] This reduces the immune system's destruction of platelets.[3]

Fostamatinib was approved for medical use in the United States in 2018 and in Europe in 2020.[1][3] In the United Kingdom a dose of 150 mg twice per day costs about £4,600 per month as of 2021.[5] This amount in the United States costs about 13,000 USD.[6]

References[edit]

  1. ^ a b "Fostamatinib Monograph for Professionals". Drugs.com. Archived from the original on 17 April 2021. Retrieved 13 December 2021.
  2. ^ a b c d e f g h "Tavalisse- fostamatinib tablet". DailyMed. 10 May 2018. Archived from the original on 28 October 2020. Retrieved 5 May 2020.
  3. ^ a b c d e "Tavlesse EPAR". European Medicines Agency (EMA). 12 November 2019. Archived from the original on 25 August 2021. Retrieved 2020-03-26. Public Domain This article incorporates text from this source, which is in the public domain.
  4. ^ "Fostamatinib (Tavalisse) Use During Pregnancy". Drugs.com. 22 October 2018. Archived from the original on 26 March 2020. Retrieved 5 May 2020.
  5. ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1081. ISBN 978-0857114105.
  6. ^ "Tavalisse Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 17 April 2021. Retrieved 13 December 2021.
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