User:Gbgaski/Intracellular transport
Intracellular transport[edit]
Intracellular transport is unique to eukaryotic cells because they possess organelles enclosed in membranes that need to be mediated for exchange of cargo to take place.[1] Intracellular transport is required for maintaining homeostasis within the cell by responding to physiological signals.[2] Proteins synthesized in the cytosol are distributed to their respective organelles, according to their specific amino acid’s sorting sequence.[3]
Fusion[edit]
Rab proteins on the surface of the transport vesicle are responsible for aligning with the complementary tethering proteins found on the respective organelle's cytosolic surface.[1] This fusion event allows for the delivery of the vesicles contents mediated by proteins such as SNARE proteins. The endoplasmic reticulum serves as a channel that proteins will pass through bound for their final destination.[1] Outbound proteins from the ER will use transport vesicles to travel along the cell cortex to reach their specific destinations.[1]
Role of microtubules[edit]
Motor proteins connect the transport vesicles to microtubules and actin filaments to facilitate intracellular movement.[2] The transport mechanism depends on the material being moved. Intracellular transport that requires quick movement will use an actin-myosin mechanism while more specialized functions require microtubules for transport.[4]
References[edit]
- ^ a b c d Alberts, Bruce,. Essential cell biology (Fifth edition ed.). New York. ISBN 978-0-393-67953-3. OCLC 1048014962.
{{cite book}}:|edition=has extra text (help)CS1 maint: extra punctuation (link) CS1 maint: multiple names: authors list (link) - ^ a b Barlan, Kari; Gelfand, Vladimir I. (2017-05). "Microtubule-Based Transport and the Distribution, Tethering, and Organization of Organelles". Cold Spring Harbor Perspectives in Biology. 9 (5): a025817. doi:10.1101/cshperspect.a025817. ISSN 1943-0264. PMC 5411697. PMID 28461574.
{{cite journal}}: Check date values in:|date=(help)CS1 maint: PMC format (link) - ^ Mellman, Ira; Nelson, W. James (2008-11). "Coordinated protein sorting, targeting and distribution in polarized cells". Nature Reviews Molecular Cell Biology. 9 (11): 833–845. doi:10.1038/nrm2525. ISSN 1471-0080. PMC 3369829. PMID 18946473.
{{cite journal}}: Check date values in:|date=(help)CS1 maint: PMC format (link) - ^ Geitmann, Anja; Nebenführ, Andreas (2015-10). Kozminski, Keith G. (ed.). "Navigating the plant cell: intracellular transport logistics in the green kingdom". Molecular Biology of the Cell. 26 (19): 3373–3378. doi:10.1091/mbc.E14-10-1482. ISSN 1059-1524. PMC 4591683. PMID 26416952.
{{cite journal}}: Check date values in:|date=(help)CS1 maint: PMC format (link)