User:Duaa Alshouly
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Propionibacterium acnes is an aerotolerant anaerobic Gram positive bacteria, rod-shaped genus from actinobacteria phylum , it is a component of the normal bacterial flora of the skin , commensal and part of the skin flora present on most healthy adult humans' skin, and play an important role in pathogenesis of acne .
Mode of action[edit]
After being engulfed and processed by phagocytes, P.acnes induces a strong Th1-type cytokine immune response by producing cytokines such as IL-12, IFN-γ and TNF-α, P.acne binds to TLR2 on monocytes and dendritic cells, leading to activation of the IL-12 promoter , IL-12, TNF-α and IFN-γ are known to be effective antitumor cytokines, P. acnes has been suggested to have antitumor activity.[1]
p.acnes was purified from normal healthy volunteers and cultured in brain-heart infusion medium and injected into dorsal skin of mice at the site where Malignant Melanoma so the tumor size at the end of observation significantly decreased , P.acnes vaccine is a promising candidate as an adjuvant potent therapy and suppressing of Melanoma.
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References[edit]
- ^ Morello S, Sorrentino R, Montinaro A, Luciano A, Maiolino P, et al. NK1.1 cells and CD8 T cells mediate the antitumor activity of Cl-IB-MECA in a mouse melanoma model. Neoplasia. 2011;13:365–373. [PMC free article] [PubMed]
- ^ Tsuda K, Yamanaka K, Lian W, Miyahara Y, Akeda T, et al.Intratumoral injection of Propionibacterium acnes suppresses malignant melanoma by enhancing Th1 immune responses.PLoS One 2011;6(12)e29020 [PMC free article] [PubMed]
Category:Bacteria Category:actionbacteria Category:Bacteria phyla