Sharon Tooze
Sharon Tooze | |
|---|---|
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| Nationality | American |
| Alma mater | College of the Holy Cross (BS) Yale University (MS) European Molecular Biology Laboratory (PhD) |
| Known for | Study of Autophagy |
| Awards | FMedSci EMBO member |
| Scientific career | |
| Fields | Cell Biology |
Sharon Tooze, FMedSci is an American cell biologist who has made significant contributions to the field of autophagy.[1] She is a senior scientist at the Francis Crick Institute and was awarded European Molecular Biology Organization (EMBO) membership in 2010.[2][3]
Education and academic career[edit]
Tooze studied for a B.S. in physics at the College of Holy Cross and a M.S. in Cellular and Molecular Biology at Yale University. Following this she went to the European Molecular Biology Laboratory (EMBL) and was awarded a PhD in Cell Biology. After a post doctoral fellowship she was promoted to staff scientist at EMBL in 1990. In 1994, Tooze moved to London to set up a lab studying the biogenesis of secretory granules at the Imperial Cancer Research Fund, later the Cancer Research UK London Research Institute (and now part of the Francis Crick Institute).
Research interests[edit]
At EMBL Sharon Tooze studied transport of a viral glycoprotein from a SARS virus and showed that O-linked glycosylation starts in the ER-Golgi intermediate compartment.[4] Later she became interested in organelle biogenesis and in how immature secretory granules form from the trans-Golgi network in neuroendocrine cells.[5][6]
In 2006, Tooze developed interest in autophagy and the biogenesis of autophagosomes. Since then her lab has identified several mammalian Atg proteins and continues to contribute to understanding of autophagy at the molecular cell biology level.[7][8][9]
Professional associations and awards[edit]
- Sharon Tooze is a member of the British Society for Cell Biology.[10]
- In 2010 Tooze was awarded EMBO membership.[3]
- In 2017, she was awarded an advanced ERC grant.[11]
- Tooze is an affiliate member of the Autophagy Inflammation and Metabolism Centre of Biomedical Research Excellence.[12]
- In 2018, she became an elected member of the Academy of Medical Sciences.[1]
References[edit]
- ^ a b "Dr Sharon Tooze". The Academy of Medical Sciences. Retrieved 2018-12-17.
- ^ "Sharon Tooze". Francis Crick Institute. Retrieved 2018-12-17.
- ^ a b "Find people in the EMBO Communities". people.embo.org. Retrieved 2018-12-17.
- ^ Warren, G.; Tooze, J.; Tooze, S. A. (1988-05-01). "Site of addition of N-acetyl-galactosamine to the E1 glycoprotein of mouse hepatitis virus-A59". The Journal of Cell Biology. 106 (5): 1475–1487. doi:10.1083/jcb.106.5.1475. ISSN 1540-8140. PMC 2115043. PMID 2836431.
- ^ Tooze, Sharon A.; Huttner, Wieland B. (1990-03-09). "Cell-free protein sorting to the regulated and constitutive secretory pathways". Cell. 60 (5): 837–847. doi:10.1016/0092-8674(90)90097-X. ISSN 0092-8674. PMC 7125605. PMID 2138058.
- ^ Huttner, Wieland B.; Weiss, Ursula; Tooze, Sharon A. (September 1990). "Requirement for GTP hydrolysis in the formation of secretory vesicles". Nature. 347 (6289): 207–208. Bibcode:1990Natur.347..207T. doi:10.1038/347207a0. ISSN 1476-4687. PMID 2118598. S2CID 4342698.
- ^ Manzoni, Claudia; Mamais, Adamantios; Dihanich, Sybille; Soutar, Marc P. M.; Plun-Favreau, Helene; Bandopadhyay, Rina; Abeti, Rosella; Giunti, Paola; Hardy, John (26 April 2018). "mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition". Bioscience Reports. 38 (2): BSR20171669. doi:10.1042/BSR20171669. ISSN 1573-4935. PMC 5968188. PMID 29563162.
- ^ Tooze, Sharon A.; Gubas, Andrea; Mercer, Thomas J. (2018-04-13). "A molecular perspective of mammalian autophagosome biogenesis". Journal of Biological Chemistry. 293 (15): 5386–5395. doi:10.1074/jbc.R117.810366. ISSN 1083-351X. PMC 5900756. PMID 29371398.
- ^ Joachim, Justin; Tooze, Sharon A. (2017-11-23). "Centrosome to autophagosome signaling: Specific GABARAP regulation by centriolar satellites". Autophagy. 13 (12): 2113–2114. doi:10.1080/15548627.2017.1385677. ISSN 1554-8627. PMC 5788548. PMID 29099272.
- ^ "Dr Sharon Tooze". British Society for Cell Biology. Retrieved 17 December 2018.
- ^ "ERC Advanced Grants 2017 - List of Principal Investigators" (PDF). European Research Council. 2017. Retrieved 17 December 2018.
- ^ "Affiliates and Council Members | Autophagy, Inflammation, and Metabolism Center of Biomedical Research Excellence". www.autophagy.center. Retrieved 2018-12-17.
| Authority control databases: Academics |
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