Draft:GcMAF in Japan

GcMAF in Japan

GcMAF is short for Gc protein-derived Macrophage Activating Factor. There are 5 types of GcMAF in Japan:

1.    Old GcMAF (1st generation)- low concentration, low stability, increased risk of cross contamination.

2.    Serum GcMAF (New generation) [1] [2][3][4][5][6][7][8] - higher concentration and stability

3.    Autologous GcMAF (New generation) - using a patient or family member’s blood.

4.    Dietary MAF (New generation) - food product in Japan

5.    Recombinant MAF (Newest generation) - can be a new medication

Old GcMAF is produced using a vitamin D3 affinity column which is used repeatedly in a room. This could increase the risk of cross contamination and that’s why old GcMAF has been stopped to be produced many years ago.

That’s why it has been focusing on developing new generation GcMAF, which is serum GcMAF, Autologous GcMAF, Dietary MAF, and Recombinant MAF.

Macrophage Morphology

Macrophages are hungry white blood cells. They engulf invading bacteria and target cells, move like amoebas. They are found in essentially all tissues.

Macrophages functions

Macrophages have very important functions such as phagocytosis of pathogens, removal of dying or dead cells, and scavenging cellular and other debris. They play a critical role in adaptive immunity, wound healing, tissue repair and regeneration.

•      Phagocytosis: detecting, engulfing and destroying pathogens

•      Removal of dying or dead cells and cellular debris

•      Scavenging senescent cells and other debris

•      Critical role in adaptive immunity

•      Wound healing, tissue repair and regeneration

GcMAF and M1 and M2 Macrophages

M1 and M2 macrophage theory sounds good, but it doesn’t match the clinical facts very well. Until 2000, Macrophages had been classified into M1 and M2 macrophages. In 2004, macrophages were classified into 4 types, M1, M2a, M2b, and M2c. In 2014, macrophages were classified into 7 types and then there were more types added.

Recent studies have revealed that the M1/M2 paradigm is not sufficient to encompass all states of macrophage activation. Actually, macrophages have the ability to change their polarization in response to different stimuli. Macrophage phenotype changes during tissue repair, switching from M1-like to M2-like phenotype. Dietary MAF has a wide variety of functions and these functions are beyond the name MAF, macrophage activating factor.

Dietary MAF can affect not only macrophages but also dendritic cells, T cells and also stem cells by extending telomere length.

•       Macrophages have the ability to change their polarization in response to different stimuli

•       Macrophage phenotype changes during tissue repair, switching from M1-like to M2-like phenotype

•       Dietary MAF does not cause the production of IL-1β and TNF-α in mice experiments (Tokushima University)

•       Dietary MAF induced increases in helper T cells and killer T cells in healthy dogs (Tottori University)

•       Dietary MAF suppressed the production of IL-4 and IL-6 in healthy dogs ( Tottori University)

•       Serum GcMAF increases the number of monocytes in the blood and the rate of maturation of dendritic cells in vitro

Tissue macrophages: Tissue resident macrophages + monocytes

Macrophages exist in nearly all tissues. Tissue resident macrophages play critical roles in repair and regeneration of each tissue. It is major to emphasize how important tissue resident macrophages are in terms of tissue repair, regeneration and rejuvenation of damaged or even normal tissue.

Clinical indications for MAF (Macrophage Activating Factor)

• Rejuvenation and Longevity     

• Infectious diseases, including antibiotics resistant bacteria and Covid-19

• Autism spectrum disorder (ASD)

• Chronic fatigue syndrome (CFS)

• Atopic dermatitis

• Cancer

• Hair loss

• Multiple sclerosis

• Pollinosis

• Autoimmune diseases

• Injuries

• Epilepsy

• Brain degenerative diseases

References

1. Pharmaceutical composition and method of preparing same [9][10][11][12][13][14]
2. Preventive and improving agents for disease associated by fatigue [15]
3. Preventive and improving agents for allergic disease [16]
4. Hair growth / hair growth promoter [17]
5. Skin improving agents [18]
6. Enzyme-treated bovine colostrum, preparation method thereof, composition, and foods and beverages [19] [20]
7. Effect of degalactosylated bovine glycoprotein formulations MAF and M сapsules on lymphopenia and clinical outcomes in hospitalized Covid-19 patients: a randomized clinical trial [21]