Dementia: Difference between revisions

Dementia
Dementia
Other names	Senility, senile dementia
	Comparison of a normal aged brain (left) and the brain of a person with Alzheimer's disease (right). Differential characteristics are pointed out.
Specialty	Neurology, psychiatry
Symptoms	Decreased ability to think and remember, emotional problems, problems with language, decreased motivation
Usual onset	Gradual
Duration	Long term
Causes	Alzheimer's disease, vascular dementia, Lewy body dementia, frontotemporal dementia
Diagnostic method	Cognitive testing (mini mental state examination)
Differential diagnosis	Delirium
Prevention	Early education, prevent high blood pressure, prevent obesity, no smoking, exercise, social engagement
Treatment	Supportive care
Medication	Cholinesterase inhibitors (small benefit)
Frequency	46 million (2015)
Deaths	1.9 million (2015)

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Dementia is a broad category of brain diseases that cause a long-term and often gradual decrease in the ability to think and remember that is great enough to affect a person's daily functioning.^[2] Other common symptoms include emotional problems, difficulties with language, and a decrease in motivation.^[2]^[3] A person's consciousness is usually not affected.^[2] A dementia diagnosis requires a change from a person's usual mental functioning and a greater decline than one would expect due to aging.^[2]^[11] These diseases also have a significant effect on a person's caregivers.^[2]

The most common type of dementia is Alzheimer's disease, which makes up 50% to 70% of cases.^[2]^[3] Other common types include vascular dementia (25%), Lewy body dementia (15%), and frontotemporal dementia.^[2]^[3] Less common causes include normal pressure hydrocephalus, Parkinson's disease dementia, syphilis, and Creutzfeldt–Jakob disease among others.^[12] More than one type of dementia may exist in the same person.^[2] A small proportion of cases run in families.^[13] In the DSM-5, dementia was reclassified as a neurocognitive disorder, with various degrees of severity.^[14] Diagnosis is usually based on history of the illness and cognitive testing with medical imaging and blood tests used to rule out other possible causes.^[4] The mini mental state examination is one commonly used cognitive test.^[3] Efforts to prevent dementia include trying to decrease risk factors such as high blood pressure, smoking, diabetes, and obesity.^[2] Screening the general population for the disorder is not recommended.^[15]

There is no known cure for dementia.^[2] Cholinesterase inhibitors such as donepezil are often used and may be beneficial in mild to moderate disorder.^[7]^[16]^[17] Overall benefit, however, may be minor.^[7]^[8] There are many measures that can improve the quality of life of people with dementia and their caregivers.^[2] Cognitive and behavioral interventions may be appropriate.^[2] Educating and providing emotional support to the caregiver is important.^[2] Exercise programs may be beneficial with respect to activities of daily living and potentially improve outcomes.^[18] Treatment of behavioral problems with antipsychotics is common but not usually recommended due to the little benefit and side effects, including an increased risk of death.^[19]^[20]

Globally, dementia affected about 46 million people in 2015.^[9] About 10% of people develop the disorder at some point in their lives.^[13] It becomes more common with age.^[21] About 3% of people between the ages of 65–74 have dementia, 19% between 75 and 84, and nearly half of those over 85 years of age.^[22] In 2013 dementia resulted in about 1.7 million deaths up from 0.8 million in 1990.^[23] As more people are living longer, dementia is becoming more common in the population as a whole.^[21] For people of a specific age, however, it may be becoming less frequent, at least in the developed world, due to a decrease in risk factors.^[21] It is one of the most common causes of disability among the old.^[3] It is believed to result in economic costs of US$604 billion a year.^[2] People with dementia are often physically or chemically restrained to a greater degree than necessary, raising issues of human rights.^[2] Social stigma against those affected is common.^[3]

Signs and symptoms

The symptoms of dementia vary across types and stages of the diagnosis.^[24] The most common affected areas include memory, visual-spatial, language, attention and problem solving. Most types of dementia are slow and progressive. By the time the person shows signs of the disorder, the process in the brain has been happening for a long time. It is possible for a patient to have two types of dementia at the same time. About 10% of people with dementia have what is known as mixed dementia, which is usually a combination of Alzheimer's disease and another type of dementia such as frontotemporal dementia or vascular dementia.^[25]^[26]

Neuropsychiatric symptoms that may be present are termed Behavioural and psychological symptoms of dementia (BPSD) and these can include:^[27]

Balance problems
Tremor
Speech and language difficulty
Trouble eating or swallowing
Memory distortions (believing that a memory has already happened when it has not, thinking an old memory is a new one, combining two memories, or confusing the people in a memory)
Wandering or restlessness
Perception and visual problems^[28]
Behavioral and psychological symptoms of dementia almost always occur in all types of dementia and may manifest as:^[29]^[30]

Agitation
Depression
Anxiety
Abnormal motor behavior
Elated mood
Irritability
Apathy
Disinhibition and impulsivity
Delusions (often believing people are stealing from them) or hallucinations
Changes in sleep or appetite.

When people with dementia are put in circumstances beyond their abilities, there may be a sudden change to crying or anger (a "catastrophic reaction").^[31]

Psychosis (often delusions of persecution) and agitation/aggression also often accompany dementia.^[32]

Mild cognitive impairment

In the first stages of dementia, the signs and symptoms of the disorder may be subtle. Often, the early signs of dementia only become apparent when looking back in time. The earliest stage of dementia is called mild cognitive impairment (MCI). 70% of those diagnosed with MCI progress to dementia at some point.^[11] In MCI, changes in the person's brain have been happening for a long time, but the symptoms of the disorder are just beginning to show. These problems, however, are not yet severe enough to affect the person's daily function. If they do, it is considered dementia. A person with MCI scores between 27 and 30 on the Mini-Mental State Examination (MMSE), which is a normal score. They may have some memory trouble and trouble finding words, but they solve everyday problems and handle their own life affairs well.^[33]

Early stages

In the early stage of dementia, the person begins to show symptoms noticeable to the people around them. In addition, the symptoms begin to interfere with daily activities. The person usually scores between a 20 and 25 on the MMSE. The symptoms are dependent on the type of dementia a person has. The person may begin to have difficulty with more complicated chores and tasks around the house or at work. The person can usually still take care of him or herself but may forget things like taking pills or doing laundry and may need prompting or reminders.^[34]

The symptoms of early dementia usually include memory difficulty, but can also include some word-finding problems (anomia) and problems with planning and organizational skills (executive function). One very good way of assessing a person's impairment is by asking if they are still able to handle their finances independently. This is often one of the first things to become problematic. Other signs might be getting lost in new places, repeating things, personality changes, social withdrawal and difficulties at work.

When evaluating a person for dementia, it is important to consider how the person was able to function five or ten years earlier. It is also important to consider a person's level of education when assessing for loss of function. For example, an accountant who can no longer balance a checkbook would be more concerning than a person who had not finished high school or had never taken care of his/her own finances.^[11]

In Alzheimer's dementia the most prominent early symptom is memory difficulty. Others include word-finding problems and getting lost. In other types of dementia, like dementia with Lewy bodies and fronto-temporal dementia, personality changes and difficulty with organization and planning may be the first signs.

Middle stages

As dementia progresses, the symptoms first experienced in the early stages of the dementia generally worsen. The rate of decline is different for each person. A person with moderate dementia scores between 6–17 on the MMSE. For example, people with Alzheimer's dementia in the moderate stages lose almost all new information very quickly. People with dementia may be severely impaired in solving problems, and their social judgment is usually also impaired. They cannot usually function outside their own home, and generally should not be left alone. They may be able to do simple chores around the house but not much else, and begin to require assistance for personal care and hygiene other than simple reminders.^[11]

Late stages

People with late-stage dementia typically turn increasingly inward and need assistance with most or all of their personal care. Persons with dementia in the late stages usually need 24-hour supervision to ensure personal safety, as well as to ensure that basic needs are being met. If left unsupervised, a person with late-stage dementia may wander or fall, may not recognize common dangers around them such as a hot stove, may not realize that they need to use the bathroom or become unable to control their bladder or bowels (incontinent).^[33]

Changes in eating frequently occur. Caregivers of people with late-stage dementia often provide pureed diets, thickened liquids, and assistance in eating, to prolong their lives, to cause them to gain weight, to reduce the risk of choking, and to make feeding the person easier.^[35] The person's appetite may decline to the point that the person does not want to eat at all. They may not want to get out of bed, or may need complete assistance doing so. Commonly, the person no longer recognizes familiar people. They may have significant changes in sleeping habits or have trouble sleeping at all.^[11]

Causes

Reversible causes

There are four main causes of easily reversible dementia: hypothyroidism, vitamin B12 deficiency, Lyme disease, and neurosyphillis. All people with memory difficulty should be checked for hypothyroidism and B12 deficiency. For Lyme disease and neurosyphilis, testing should be done if there are risk factors for those diseases in the person. Because risk factors are often difficult to determine, testing for neurosyphillis and Lyme disease, as well as other mentioned factors, may be undertaken as a matter of course in cases where dementia is suspected.^[11]^: 31–32

Alzheimer's disease

Alzheimer's disease accounts for 50% to 70% of cases of dementia.^[2]^[3] The most common symptoms of Alzheimer's disease are short-term memory loss and word-finding difficulties. People with Alzheimer's disease also have trouble with visual-spatial areas (for example, they may begin to get lost often), reasoning, judgment, and insight. Insight refers to whether or not the person realizes he/she has memory problems.

Common early symptoms of Alzheimer's include repetition, getting lost, difficulties keeping track of bills, problems with cooking especially new or complicated meals, forgetting to take medication, and word-finding problems.

The part of the brain most affected by Alzheimer's is the hippocampus. Other parts of the brain that show shrinking (atrophy) include the temporal and parietal lobes.^[11] Although this pattern suggests Alzheimer's, the brain shrinkage in Alzheimer's disease is very variable, and a scan of the brain cannot actually make the diagnosis. The relationship between undergoing anesthesia and AD is unclear.^[36]

Vascular dementia

Vascular dementia is the cause of at least 20% of dementia cases, making it the second most common cause of dementia.^[37] It is caused by disease or injury affecting the blood supply to the brain, typically involving a series of minor strokes. The symptoms of this dementia depend on where in the brain the strokes have occurred and whether the vessels are large or small.^[11] Multiple injuries can cause progressive dementia over time, while a single injury located in an area critical for cognition (i.e. hippocampus, thalamus) can lead to sudden cognitive decline.^[37]

On scans of the brain, a person with vascular dementia may show evidence of multiple strokes of different sizes in various locations. People with vascular dementia tend to have risk factors for disease of the blood vessels, such as tobacco use, high blood pressure, atrial fibrillation, high cholesterol or diabetes, or other signs of vascular disease such as a previous heart attack or angina.

Dementia with Lewy bodies

Dementia with Lewy bodies (DLB) is a dementia that has the primary symptoms of visual hallucinations and "Parkinsonism". Parkinsonism is the symptoms of Parkinson's disease, which includes tremor, rigid muscles, and a face without emotion. The visual hallucinations in DLB are generally very vivid hallucinations of people or animals and they often occur when someone is about to fall asleep or just waking up. Other prominent symptoms include problems with attention, organization, problem solving and planning (executive function), and difficulty with visual-spatial function.^[11]

Again, imaging studies cannot necessarily make the diagnosis of DLB, but some signs are particularly common. A person with DLB often shows occipital hypoperfusion on SPECT scan or occipital hypometabolism on a PET scan. Generally, a diagnosis of DLB is straightforward and unless it is complicated, a brain scan is not always necessary.^[11]

Frontotemporal dementia

Frontotemporal dementias (FTDs) are characterized by drastic personality changes and language difficulties. In all FTDs, the person has a relatively early social withdrawal and early lack of insight into the disorder. Memory problems are not a main feature of this disorder.^[11]

There are three main types of FTD. The first has major symptoms in the area of personality and behavior. This is called behavioral variant FTD (bv-FTD) and is the most common. In bv-FTD, the person shows a change in personal hygiene, becomes rigid in their thinking, and rarely recognize that there is a problem, they are socially withdrawn, and often have a drastic increase in appetite. They may also be socially inappropriate. For example, they may make inappropriate sexual comments, or may begin using pornography openly when they had not before. One of the most common signs is apathy, or not caring about anything. Apathy, however, is a common symptom in many different dementias.^[11]

The other two types of FTD feature language problems as the main symptom. The second type is called semantic dementia or temporal variant dementia (TV-FTD). The main feature of this is the loss of the meaning of words. It may begin with difficulty naming things. The person eventually may also lose the meaning of objects as well. For example, a drawing of a bird, dog, and an airplane in someone with FTD may all appear just about the same.^[11] In a classic test for this, a patient is shown a picture of a pyramid and below there is a picture of both a palm tree and a pine tree. The person is asked to say which one goes best with the pyramid. In TV-FTD the person would not be able to answer that question.

The last type of FTD is called progressive non-fluent aphasia (PNFA). This is mainly a problem with producing speech. They have trouble finding the right words, but mostly they have a difficulty coordinating the muscles they need to speak. Eventually, someone with PNFA only uses one-syllable words or may become totally mute.

Progressive supranuclear palsy

Progressive supranuclear palsy (PSP) is a form of dementia that is characterized by problems with eye movements. Generally the problems begin with difficulty moving the eyes up or down (vertical gaze palsy). Since difficulty moving the eyes upward can sometimes happen in normal aging, problems with downward eye movements are the key in PSP. Other key symptoms of PSP include falling backwards, balance problems, slow movements, rigid muscles, irritability, apathy, social withdrawal, and depression. The person may also have certain "frontal lobe signs" such as perseveration, a grasp reflex and utilization behavior (the need to use an object once you see it). People with PSP often have progressive difficulty eating and swallowing, and eventually with talking as well. Because of the rigidity and slow movements, PSP is sometimes misdiagnosed as Parkinson's disease.

On scans of the brain, the midbrain of people with PSP is generally shrunken (atrophied), but there are no other common brain abnormalities visible on images of the person's brain.

Corticobasal degeneration

Corticobasal degeneration is a rare form of dementia that is characterized by many different types of neurological problems that get progressively worse over time. This is because the disorder affects the brain in many different places, but at different rates. One common sign is difficulty with using only one limb. One symptom that is extremely rare in any condition other than corticobasal degeneration is the "alien limb." The alien limb is a limb of the person that seems to have a mind of its own, it moves without control of the person's brain. Other common symptoms include jerky movements of one or more limbs (myoclonus), symptoms that are different in different limbs (asymmetric), difficulty with speech that is due to not being able to move the mouth muscles in a coordinated way, numbness and tingling of the limbs and neglecting one side of the person's vision or senses. In neglect, a person ignores the opposite side of the body from the one that has the problem. For example, a person may not feel pain on one side, or may only draw half of a picture when asked. In addition, the person's affected limbs may be rigid or have muscle contractions causing strange repetitive movements (dystonia).^[11]

The area of the brain most often affected in corticobasal degeneration is the posterior frontal lobe and parietal lobe. Still, many other part of the brain can be affected.^[11]

Rapidly progressive

Creutzfeldt–Jakob disease typically causes a dementia that worsens over weeks to months, and is caused by prions. The common causes of slowly progressive dementia also sometimes present with rapid progression: Alzheimer's disease, dementia with Lewy bodies, frontotemporal lobar degeneration (including corticobasal degeneration and progressive supranuclear palsy).

On the other hand, encephalopathy or delirium may develop relatively slowly and resemble dementia. Possible causes include brain infection (viral encephalitis, subacute sclerosing panencephalitis, Whipple's disease) or inflammation (limbic encephalitis, Hashimoto's encephalopathy, cerebral vasculitis); tumors such as lymphoma or glioma; drug toxicity (e.g., anticonvulsant drugs^[specify]); metabolic causes such as liver failure or kidney failure; and chronic subdural hematoma.

Immunologically mediated

Chronic inflammatory conditions that may affect the brain and cognition include Behçet's disease, multiple sclerosis, sarcoidosis, Sjögren's syndrome, systemic lupus erythematosus, celiac disease, and non-celiac gluten sensitivity.^[38]^[39] These types of dementias can rapidly progress, but usually have a good response to early treatment. This consists of immunomodulators or steroid administration, or in certain cases, the elimination of the causative agent.^[39]

Other conditions

There are many other medical and neurological conditions in which dementia only occurs late in the illness. For example, a proportion of patients with Parkinson's disease develop dementia, though widely varying figures are quoted for this proportion.^[40] When dementia occurs in Parkinson's disease, the underlying cause may be dementia with Lewy bodies or Alzheimer's disease, or both.^[41] Cognitive impairment also occurs in the Parkinson-plus syndromes of progressive supranuclear palsy and corticobasal degeneration (and the same underlying pathology may cause the clinical syndromes of frontotemporal lobar degeneration). Although the acute porphyrias may cause episodes of confusion and psychiatric disturbance, dementia is a rare feature of these rare diseases.

Aside from those mentioned above, inherited conditions that can cause dementia (alongside other symptoms) include:^[42]

Mild cognitive impairment

Mild cognitive impairment means that the person exhibits memory or thinking difficulties, but those difficulties are not severe enough to meet criteria for a diagnosis of dementia.^[43] They should score between 25–30 on the MMSE.^[11] Around 70% of people with MCI go on to develop some form of dementia.^[11] MCI is generally divided into two categories. The first is one that is primarily memory loss (amnestic MCI). The second category is anything that is not primarily memory difficulties (non-amnestic MCI). People with primarily memory problems generally go on to develop Alzheimer's disease. People with the other type of MCI may go on to develop other types of dementia.

Diagnosis of MCI is often difficult, as cognitive testing may be normal. Often, more in-depth neuropsychological testing is necessary to make the diagnosis. the most commonly used criteria are called the Peterson criteria and include:

Memory or other cognitive (thought-processing) complaint by the person or a person who knows the patient well.
The person must have a memory or other cognitive problem as compared to a person of the same age and level of education.
The problem must not be severe enough to affect the person's daily function.
The person must not have dementia.

Fixed cognitive impairment

Various types of brain injury may cause irreversible cognitive impairment that remains stable over time. Traumatic brain injury may cause generalized damage to the white matter of the brain (diffuse axonal injury), or more localized damage (as also may neurosurgery). A temporary reduction in the brain's supply of blood or oxygen may lead to hypoxic-ischemic injury. Strokes (ischemic stroke, or intracerebral, subarachnoid, subdural or extradural hemorrhage) or infections (meningitis or encephalitis) affecting the brain, prolonged epileptic seizures, and acute hydrocephalus may also have long-term effects on cognition. Excessive alcohol use may cause alcohol dementia, Wernicke's encephalopathy, or Korsakoff's psychosis.

Slowly progressive

Dementia that begins gradually and worsens progressively over several years is usually caused by neurodegenerative disease—that is, by conditions that affect only or primarily the neurons of the brain and cause gradual but irreversible loss of function of these cells. Less commonly, a non-degenerative condition may have secondary effects on brain cells, which may or may not be reversible if the condition is treated.

Causes of dementia depend on the age when symptoms begin. In the elderly population (usually defined in this context as over 65 years of age), a large majority of dementia cases are caused by Alzheimer's disease, vascular dementia, or both. Dementia with Lewy bodies is another commonly exhibited form, which again may occur alongside either or both of the other causes.^[44]^[45]^[46] Hypothyroidism sometimes causes slowly progressive cognitive impairment as the main symptom, and this may be fully reversible with treatment. Normal pressure hydrocephalus, though relatively rare, is important to recognize since treatment may prevent progression and improve other symptoms of the condition. However, significant cognitive improvement is unusual.

Dementia is much less common under 65 years of age. Alzheimer's disease is still the most frequent cause, but inherited forms of the disorder account for a higher proportion of cases in this age group. Frontotemporal lobar degeneration and Huntington's disease account for most of the remaining cases.^[47] Vascular dementia also occurs, but this in turn may be due to underlying conditions (including antiphospholipid syndrome, CADASIL, MELAS, homocystinuria, moyamoya, and Binswanger's disease). People who receive frequent head trauma, such as boxers or football players, are at risk of chronic traumatic encephalopathy^[48] (also called dementia pugilistica in boxers).

In young adults (up to 40 years of age) who were previously of normal intelligence, it is very rare to develop dementia without other features of neurological disease, or without features of disease elsewhere in the body. Most cases of progressive cognitive disturbance in this age group are caused by psychiatric illness, alcohol or other drugs, or metabolic disturbance. However, certain genetic disorders can cause true neurodegenerative dementia at this age. These include familial Alzheimer's disease, SCA17 (dominant inheritance); adrenoleukodystrophy (X-linked); Gaucher's disease type 3, metachromatic leukodystrophy, Niemann-Pick disease type C, pantothenate kinase-associated neurodegeneration, Tay-Sachs disease, and Wilson's disease (all recessive). Wilson's disease is particularly important since cognition can improve with treatment.

At all ages, a substantial proportion of patients who complain of memory difficulty or other cognitive symptoms have depression rather than a neurodegenerative disease. Vitamin deficiencies and chronic infections may also occur at any age; they usually cause other symptoms before dementia occurs, but occasionally mimic degenerative dementia. These include deficiencies of vitamin B₁₂, folate, or niacin, and infective causes including cryptococcal meningitis, AIDS, Lyme disease, progressive multifocal leukoencephalopathy, subacute sclerosing panencephalitis, syphilis, and Whipple's disease.

Diagnosis

As seen above, there are many specific types and causes of dementia, often showing slightly different symptoms. However, the symptoms are very similar and it is usually difficult to diagnose the type of dementia by symptoms alone. Diagnosis may be aided by brain scanning techniques. In many cases, the diagnosis cannot be absolutely sure except with a brain biopsy, but this is very rarely recommended (though it can be performed at autopsy). In those who are getting older, general screening for cognitive impairment using cognitive testing or early diagnosis of dementia has not been shown to improve outcomes.^[49] However, it has been shown that screening exams are useful in those people over the age of 65 with memory complaints.^[11]

Normally, symptoms must be present for at least six months to support a diagnosis.^[50] Cognitive dysfunction of shorter duration is called delirium. Delirium can be easily confused with dementia due to similar symptoms. Delirium is characterized by a sudden onset, fluctuating course, a short duration (often lasting from hours to weeks), and is primarily related to a somatic (or medical) disturbance. In comparison, dementia has typically a long, slow onset (except in the cases of a stroke or trauma), slow decline of mental functioning, as well as a longer duration (from months to years).^[51]

Some mental illnesses, including depression and psychosis, may produce symptoms that must be differentiated from both delirium and dementia.^[52] Therefore, any dementia evaluation should include a depression screening such as the Neuropsychiatric Inventory or the Geriatric Depression Scale.^[11] Physicians used to think that anyone who came in with memory complaints had depression and not dementia (because they thought that those with dementia are generally unaware of their memory problems). This is called pseudodementia. However, in recent years researchers have realized that many older people with memory complaints in fact have MCI, the earliest stage of dementia. Depression should always remain high on the list of possibilities, however, for an elderly person with memory trouble.

Changes in thinking, hearing and vision are associated with normal ageing and can cause problems when diagnosing dementia due to the similarities.^[53]

Cognitive testing

Sensitivity and specificity of common tests for dementia
Test	Sensitivity	Specificity	Reference
MMSE	71%–92%	56%–96%	^[54]
3MS	83%–93.5%	85%–90%	^[55]
AMTS	73%–100%	71%–100%	^[55]

There are some brief tests (5–15 minutes) that have reasonable reliability to screen for dementia. While many tests have been studied,^[56]^[57]^[58] presently the mini mental state examination (MMSE) is the best studied and most commonly used. The MMSE is a useful tool for helping to diagnose dementia if the results are interpreted along with an assessment of a person's personality, their ability to perform activities of daily living, and their behaviour.^[59] Other cognitive tests include the abbreviated mental test score (AMTS), the, Modified Mini-Mental State Examination (3MS),^[60] the Cognitive Abilities Screening Instrument (CASI),^[61] the Trail-making test,^[62] and the clock drawing test.^[63] The MOCA (Montreal Cognitive Assessment) is a very reliable screening test and is available online for free in 35 different languages.^[11] The MOCA has also been shown somewhat better at detecting mild cognitive impairment than the MMSE.^[64] Brief cognitive tests may be affected by factors such as age, education and ethnicity.^[65]

Another approach to screening for dementia is to ask an informant (relative or other supporter) to fill out a questionnaire about the person's everyday cognitive functioning. Informant questionnaires provide complementary information to brief cognitive tests. Probably the best known questionnaire of this sort is the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE).^[66] There is not sufficient evidence to determine how accurate the IQCODE is for diagnosing or predicting dementia.^[67] The Alzheimer's Disease Caregiver Questionnaire is another tool. It is about 90% accurate for Alzheimer's and can be completed online or in the office by a caregiver.^[11] On the other hand, the General Practitioner Assessment Of Cognition combines both, a patient assessment and an informant interview. It was specifically designed for the use in the primary care setting.

Clinical neuropsychologists provide diagnostic consultation following administration of a full battery of cognitive testing, often lasting several hours, to determine functional patterns of decline associated with varying types of dementia. Tests of memory, executive function, processing speed, attention, and language skills are relevant, as well as tests of emotional and psychological adjustment. These tests assist with ruling out other etiologies and determining relative cognitive decline over time or from estimates of prior cognitive abilities.

Laboratory tests

Routine blood tests are also usually performed to rule out treatable causes. These tests include vitamin B₁₂, folic acid, thyroid-stimulating hormone (TSH), C-reactive protein, full blood count, electrolytes, calcium, renal function, and liver enzymes. Abnormalities may suggest vitamin deficiency, infection, or other problems that commonly cause confusion or disorientation in the elderly.^{[citation needed]}

Imaging

A CT scan or magnetic resonance imaging (MRI scan) is commonly performed, although these tests do not pick up diffuse metabolic changes associated with dementia in a person that shows no gross neurological problems (such as paralysis or weakness) on neurological exam.^{[citation needed]} CT or MRI may suggest normal pressure hydrocephalus, a potentially reversible cause of dementia, and can yield information relevant to other types of dementia, such as infarction (stroke) that would point at a vascular type of dementia.

The functional neuroimaging modalities of SPECT and PET are more useful in assessing long-standing cognitive dysfunction, since they have shown similar ability to diagnose dementia as a clinical exam and cognitive testing.^[68] The ability of SPECT to differentiate the vascular cause (i.e., multi-infarct dementia) from Alzheimer's disease dementias, appears superior to differentiation by clinical exam.^[69]

Recent research has established the value of PET imaging using carbon-11 Pittsburgh Compound B as a radiotracer (PIB-PET) in predictive diagnosis of various kinds of dementia, in particular Alzheimer's disease. Studies from Australia have found PIB-PET 86% accurate in predicting which patients with mild cognitive impairment will develop Alzheimer's disease within two years. In another study, carried out using 66 patients seen at the University of Michigan, PET studies using either PIB or another radiotracer, carbon-11 dihydrotetrabenazine (DTBZ), led to more accurate diagnosis for more than one-fourth of patients with mild cognitive impairment or mild dementia.^[70]

Prevention

A number of factors can decrease the risk of dementia.^[6] A group of efforts is believed to be able to prevent a third of cases and include early education, treating high blood pressure, preventing obesity, preventing hearing loss, treating depression, being active, preventing diabetes, not smoking, and preventing social isolation.^[6] A 2018 review however concluded that no medications have good evidence of a preventative effect including blood pressure medications.^[71]

Among otherwise healthy older people, computerized cognitive training may improve memory. However it is not known if it prevents dementia.^[72]^[73] Short term exercise has limited evidence.^[74] In those with normal mental function evidence for medications is poor.^[75] The same applies to supplements.^[76]

Management

Except for the treatable types listed above, there is no cure. Cholinesterase inhibitors are often used early in the disorder course; however, benefit is generally small.^[8]^[77] Cognitive and behavioral interventions may be appropriate. There is some evidence that educating and providing support for the person with dementia, as well as caregivers and family members, improves outcomes.^[78] Exercise programs are beneficial with respect to activities of daily living and potentially improve dementia.^[18]

Psychological therapies

Psychological therapies for dementia include some limited evidence for reminiscence therapy (namely, some positive effects in the areas of quality of life, cognition, communication and mood - the first three particularly in care home settings),^[79] some benefit for cognitive reframing for caretakers,^[80] unclear evidence for validation therapy,^[81] and tentative evidence for mental exercises, such as cognitive stimulation programs for people with mild to moderate dementia.^[82] Reminiscence therapy can improve quality of life, cognition, communication, and possibly mood in people with dementia in some circumstances, although all of these benefits may be small.^[83]

Adult daycare centers as well as special care units in nursing homes often provide specialized care for dementia patients. Adult daycare centers offer supervision, recreation, meals, and limited health care to participants, as well as providing respite for caregivers. In addition, home care can provide one-on-one support and care in the home allowing for more individualized attention that is needed as the disorder progresses. Psychiatric nurses can make a distinctive contribution to people's mental health.^[84]

Since dementia impairs normal communication due to changes in receptive and expressive language, as well as the ability to plan and problem solve, agitated behaviour is often a form of communication for the person with dementia. Actively searching for a potential cause, such as pain, physical illness, or overstimulation can be helpful in reducing agitation.^[85] Additionally, using an "ABC analysis of behaviour" can be a useful tool for understanding behavior in people with dementia. It involves looking at the antecedents (A), behavior (B), and consequences (C) associated with an event to help define the problem and prevent further incidents that may arise if the person's needs are misunderstood.^[86] The strongest evidence for non-pharmacological therapies for the management of changed behaviours in dementia is for using such approaches.^[87] There is low quality evidence that regular (at least five sessions of) music therapy may be help resident in institutions. It may reduce depressive symptoms and improves overall behavioural problems. There may also be a beneficial effect on emotional well-being and quality of life, as well as reducing anxiety.^[88]

Medications

No medications have been shown to prevent or cure dementia.^[89] Medications may be used to treat the behavioural and cognitive symptoms but have no effect on the underlying disease process.^[11]^[90]

Acetylcholinesterase inhibitors, such as donepezil, may be useful for Alzheimer disease^[91] and dementia in Parkinson's, DLB, or vascular dementia.^[90] The quality of the evidence however is poor^[92] and the benefit is small.^[8] No difference has been shown between the agents in this family.^[16] In a minority of people side effects include a slow heart rate and fainting.^[93]

As assessment for an underlying cause of the behavior is needed before prescribing antipsychotic medication for symptoms of dementia.^[94] Antipsychotic drugs should be used to treat dementia only if non-drug therapies have not worked, and the person's actions threaten themselves or others.^[95]^[96]^[97]^[98] Aggressive behavior changes are sometimes the result of other solvable problems, that could make treatment with antipsychotics unnecessary.^[95] Because people with dementia can be aggressive, resistant to their treatment, and otherwise disruptive, sometimes antipsychotic drugs are considered as a therapy in response.^[95] These drugs have risky adverse effects, including increasing the person's chance of stroke and death.^[95] Given these adverse events and small benefit antipsychotics should be avoided whenever possible.^[87] Generally, stopping antipsychotics for people with dementia does not cause problems, even in those who have been on them a long time.^[99]

N-methyl-D-aspartate (NMDA) receptor blockers such as memantine may be of benefit but the evidence is less conclusive than for AChEIs.^[100] Due to their differing mechanisms of action memantine and acetylcholinesterase inhibitors can be used in combination however the benefit is slight.^[101]^[102]

While depression is frequently associated with dementia, selective serotonin reuptake inhibitors (SSRIs) do not appear to affect outcomes.^[103]^[104]^{[needs update]} The SSRIs sertraline and citalopram have been demonstrated to reduce symptoms of agitation, compared to placebo.^[105]

The use of medications to alleviate sleep disturbances that people with dementia often experience has not been well researched, even for medications that are commonly prescribed.^[106] In 2012 the American Geriatrics Society recommended that benzodiazepines such as diazepam, and non-benzodiazepine hypnotics, be avoided for people with dementia due to the risks of increased cognitive impairment and falls.^[107] Additionally, there is little evidence for the effectiveness of benzodiazepines in this population.^[106]^[108] There is no clear evidence that melatonin or ramelteon improves sleep for people with dementia due to Alzheimer's disease.^[106] There is limited evidence that a low dose of trazodone may improve sleep, however more research is needed.^[106]

There is no solid evidence that folate or vitamin B12 improves outcomes in those with cognitive problems.^[109] Statins also have no benefit in dementia.^[110] Medications for other health conditions may need to be managed differently for a person who also has a diagnosis of dementia. The MATCH-D criteria can help identify ways that a diagnosis of dementia changes medication management for other health conditions.^[111] It is unclear if there is a link between blood pressure medication and dementia. There is a possibility that people may experience an increase in cardiovascular-related events if these medications are withdrawn.^[112]

Pain

As people age, they experience more health problems, and most health problems associated with aging carry a substantial burden of pain; therefore, between 25% and 50% of older adults experience persistent pain. Seniors with dementia experience the same prevalence of conditions likely to cause pain as seniors without dementia.^[113] Pain is often overlooked in older adults and, when screened for, often poorly assessed, especially among those with dementia since they become incapable of informing others that they're in pain.^[113]^[114] Beyond the issue of humane care, unrelieved pain has functional implications. Persistent pain can lead to decreased ambulation, depressed mood, sleep disturbances, impaired appetite, and exacerbation of cognitive impairment,^[114] and pain-related interference with activity is a factor contributing to falls in the elderly.^[113]^[115]

Although persistent pain in the person with dementia is difficult to communicate, diagnose, and treat, failure to address persistent pain has profound functional, psychosocial, and quality of life implications for this vulnerable population. Health professionals often lack the skills and usually lack the time needed to recognize, accurately assess, and adequately monitor pain in people with dementia.^[113]^[116] Family members and friends can make a valuable contribution to the care of a person with dementia by learning to recognize and assess their pain. Educational resources (such as the Understand Pain and Dementia tutorial) and observational assessment tools are available.^[113]^[117]^[118]

Eating difficulties

Persons with dementia may have difficulty eating. Whenever it is available as an option, the recommended response to eating problems is having a caretaker do assisted feeding for the person.^[95] A secondary option for people who cannot swallow effectively is to consider gastrostomy feeding tube placement as a way to give nutrition. However, in bringing person comfort and keeping functional status while lowering risk of aspiration pneumonia and death, assistance with oral feeding is at least as good as tube feeding.^[95]^[119] Tube-feeding is associated with agitation, increased use of physical and chemical restraints, and worsening pressure ulcers. Tube feedings may also cause fluid overload, diarrhea, abdominal pain, local complications, less human interaction, and may increase the risk of aspiration.^[120]^[121]

Benefits of this procedure in those with advanced dementia has not been shown.^[122] The risks of using tube feeding include agitation, the person pulling out the tube or otherwise being physically or chemically immobilized to prevent them from doing this, or getting pressure ulcers.^[95] There is about a 1% fatality rate directly related to the procedure^[123] with a 3% major complication rate.^[124] The percentage of people at the end of their life with dementia using feeding tubes in the USA has dropped from 12% in 2000 to 6% as of 2014.^[125]^[126]

Alternative medicine

Aromatherapy and massage have unclear evidence.^[127]^[128] There have been studies on the efficacy and safety of cannabinoids in relieving behavioral and psychological symptoms of dementia.^[129]

Omega-3 fatty acid supplements from plants or fish sources do not appear to benefit or harm people with mild to moderate Alzheimer's disease. It is unclear if taking omega-3 fatty acid supplements can improve other types of dementia.^[130]

Palliative care

Given the progressive and terminal nature of dementia, palliative care can be helpful to patients and their caregivers by helping both people with the disorder and their caregivers understand what to expect, deal with loss of physical and mental abilities, plan out a patient's wishes and goals including surrogate decision making, and discuss wishes for or against CPR and life support.^[131]^[132] Because the decline can be rapid, and because most people prefer to allow the person with dementia to make their own decisions, palliative care involvement before the late stages of dementia is recommended.^[133]^[134] Further research is required to determine the appropriate palliative care interventions and how well they help people with advanced dementia.^[135]

Person-centered care helps maintain the dignity of people with dementia.^[136]

Epidemiology

The number of cases of dementia worldwide in 2010 was estimated at 35.6 million.^[137] In 2015, 46.8 million people live with dementia, with 58% living in low and middle income countries.^[138] The prevalence of dementia differs in different world regions, ranging from 4.7% in Central Europe to 8.7% in North Africa/Middle East; the prevalence in other regions is estimated to be between 5.6 and 7.6% .^[138] The number of people living with dementia is estimated to double every 20 years. In 2013 dementia resulted in about 1.7 million deaths, up from 0.8 million in 1990.^[23] Around two thirds of individuals with dementia live in low- and middle-income countries, where the sharpest increases in numbers are predicted.^[137]

The annual incidence of dementia is over 9.9 million worldwide. Almost half of the new cases of dementia occur in Asia, followed by Europe (25%), the Americas (18%) and Africa (8%). The incidence of dementia increases exponentially with increase in age, doubling with every 6.3 year increase in age.^[138] Dementia affecting 5% of the population older than 65 and 20–40% of those older than 85.^[139] Rates are slightly higher in women than men at ages 65 and greater.^[139]

Dementia impacts not only the individuals with dementia, but also their carers and the wider society. Among people aged 60 years and over, dementia is ranked the 9th most burdensome condition according to the 2010 Global Burden of Disease (GBD) estimates.The global costs of dementia is around US$818 billion in 2015, a 35.4% increase from US$604 billion in 2010.^[138]

History

Until the end of the 19th century, dementia was a much broader clinical concept. It included mental illness and any type of psychosocial incapacity, including conditions that could be reversed.^[140] Dementia at this time simply referred to anyone who had lost the ability to reason, and was applied equally to psychosis of mental illness, "organic" diseases like syphilis that destroy the brain, and to the dementia associated with old age, which was attributed to "hardening of the arteries".

Dementia has been referred to in medical texts since antiquity. One of the earliest known allusions to dementia is attributed to the 7th-century BC Greek philosopher Pythagoras, who divided the human lifespan into six distinct phases, which were 0–6 (infancy), 7–21 (adolescence), 22–49 (young adulthood), 50–62 (middle age), 63–79 (old age), and 80–death (advanced age). The last two he described as the "senium", a period of mental and physical decay, and of the final phase being where "the scene of mortal existence closes after a great length of time that very fortunately, few of the human species arrive at, where the mind is reduced to the imbecility of the first epoch of infancy".^[141] In 550 BC, the Greek Athenian statesman and poet Solon argued that the terms of a man's will might be invalidated if he exhibited loss of judgement due to advanced age. Chinese medical texts made allusions to the condition as well, and the characters for "dementia" translate literally to "foolish old person".^{[citation needed]}

Aristotle and Plato from Ancient Greece spoke of the mental decay of advanced age, but apparently simply viewed it as an inevitable process that affected all old men, and which nothing could prevent. Plato stated that the elderly were unsuited for any position of responsibility because, "There is not much acumen of the mind that once carried them in their youth, those characteristics one would call judgement, imagination, power of reasoning, and memory. They see them gradually blunted by deterioration and can hardly fulfill their function."^{[citation needed]}

For comparison, the Roman statesman Cicero held a view much more in line with modern-day medical wisdom that loss of mental function was not inevitable in the elderly and "affected only those old men who were weak-willed". He spoke of how those who remained mentally active and eager to learn new things could stave off dementia. However, Cicero's views on aging, although progressive, were largely ignored in a world that would be dominated by Aristotle's medical writings for centuries. Subsequent physicians during the time of Roman Empire such as Galen and Celsus simply repeated the beliefs of Aristotle while adding few new contributions to medical knowledge.

Byzantine physicians sometimes wrote of dementia, and it is recorded that at least seven emperors whose lifespans exceeded the age of 70 displayed signs of cognitive decline. In Constantinople, there existed special hospitals to house those diagnosed with dementia or insanity, but these naturally did not apply to the emperors who were above the law and whose health conditions could not be publicly acknowledged.

Otherwise, little is recorded about dementia in Western medical texts for nearly 1700 years. One of the few references to it was the 13th-century friar Roger Bacon, who viewed old age as divine punishment for original sin. Although he repeated existing Aristotelian beliefs that dementia was inevitable after a long enough lifespan, he did make the extremely progressive assertion that the brain was the center of memory and thought rather than the heart.

Poets, playwrights, and other writers however made frequent allusions to the loss of mental function in old age. Shakespeare notably mentions it in some of his plays including Hamlet and King Lear.

During the 19th century, doctors generally came to believe that dementia in the elderly was the result of cerebral atherosclerosis, although opinions fluctuated between the idea that it was due to blockage of the major arteries supplying the brain or small strokes within the vessels of the cerebral cortex. This viewpoint remained conventional medical wisdom through the first half of the 20th century, but by the 1960s was increasingly challenged as the link between neurodegenerative diseases and age-related cognitive decline was established. By the 1970s, the medical community maintained that vascular dementia was rarer than previously thought and Alzheimer's disease caused the vast majority of mental impairments in old age. More recently however, it is believed that dementia is often a mixture of both conditions.

Much like other diseases associated with aging, dementia was comparatively rare before the 20th century, due to the fact that it is most common in people over 80, and such lifespans were uncommon in preindustrial times. Conversely, syphilitic dementia was widespread in the developed world until largely being eradicated by the use of penicillin after WWII. With significant increases in life expectancy following WWII, the number of people in developed countries over 65 started rapidly climbing. While elderly persons constituted an average of 3–5% of the population prior to 1945, by 2010 it was common in many countries to have 10–14% of people over 65 and in Germany and Japan, this figure exceeded 20%. Public awareness of Alzheimer's Disease was greatly increased in 1994 when former US president Ronald Reagan announced that he had been diagnosed with the condition.

In the more recent history of dementia, some hospitals in London have found that using color, designs, pictures and lights have helped dementia patients adjust to being at the hospital. These adjustments to the layout of the dementia wings at these hospitals have helped patients by preventing confusion.^[142]

Terminology

Dementia in the elderly has previously been called senile dementia or senility, and viewed as a normal and somewhat inevitable aspect of growing old, rather than as being caused by any specific diseases. The terminology, "senile dementia" or "senility", is no longer recommended.^[143]^[144] In 1907, a specific organic dementing process of early onset, called Alzheimer's disease, was described. This was associated with particular microscopic changes in the brain, but was seen as a rare disease of middle age because the first person diagnosed with it was a 50-year-old woman.

By the period of 1913–20, schizophrenia had been well-defined in a way similar to today, and also the term dementia praecox had been used to suggest the development of senile-type dementia at a younger age. Eventually the two terms fused, so that until 1952 physicians used the terms dementia praecox (precocious dementia) and schizophrenia interchangeably. The term precocious dementia for a mental illness suggested that a type of mental illness like schizophrenia (including paranoia and decreased cognitive capacity) could be expected to arrive normally in all persons with greater age (see paraphrenia). After about 1920, the beginning use of dementia for what is now understood as schizophrenia and senile dementia helped limit the word's meaning to "permanent, irreversible mental deterioration". This began the change to the more recognizable use of the term today.

In 1976, neurologist Robert Katzmann suggested a link between senile dementia and Alzheimer's disease.^[145] Katzmann suggested that much of the senile dementia occurring (by definition) after the age of 65, was pathologically identical with Alzheimer's disease occurring before age 65 and therefore should not be treated differently. He noted that "senile dementia" not being considered a disease, but rather part of aging, was keeping millions of aged patients experiencing what otherwise was identical with Alzheimer's disease from being diagnosed as having a disease process, rather than simply considered as aging normally.^[146] Katzmann thus suggested that Alzheimer's disease, if taken to occur over age 65, is actually common, not rare, and was the fourth- or 5th-leading cause of death, even though rarely reported on death certificates in 1976.

This suggestion opened the view that dementia is never normal, and must always be the result of a particular disease process, and is not part of the normal healthy aging process, per se. The ensuing debate led for a time to the proposed disease diagnosis of "senile dementia of the Alzheimer's type" (SDAT) in persons over the age of 65, with "Alzheimer's disease" diagnosed in persons younger than 65 who had the same pathology. Eventually, however, it was agreed that the age limit was artificial, and that Alzheimer's disease was the appropriate term for persons with the particular brain pathology seen in this disorder, regardless of the age of the person with the diagnosis. A helpful finding was that although the incidence of Alzheimer's disease increased with age (from 5–10% of 75-year-olds to as many as 40–50% of 90-year-olds), there was no age at which all persons developed it, so it was not an inevitable consequence of aging, no matter how great an age a person attained. Evidence of this is shown by numerous documented supercentenarians (people living to 110 or more) that experienced no serious cognitive impairment. There is some evidence that dementia is most likely to develop between the ages of 80 and 84 and individuals who pass that point without being affected have a lower chance of developing it. Women account for a larger percentage of dementia cases than men, although this can be attributed to their longer overall lifespan and greater odds of attaining an age where the condition is likely to occur.^{[citation needed]}

Also, after 1952, mental illnesses like schizophrenia were removed from the category of organic brain syndromes, and thus (by definition) removed from possible causes of "dementing illnesses" (dementias). At the same, however, the traditional cause of senile dementia – "hardening of the arteries" – now returned as a set of dementias of vascular cause (small strokes). These were now termed multi-infarct dementias or vascular dementias.

In the 21st century, a number of other types of dementia have been differentiated from Alzheimer's disease and vascular dementias (these two being the most common types). This differentiation is on the basis of pathological examination of brain tissues, by symptomatology, and by different patterns of brain metabolic activity in nuclear medical imaging tests such as SPECT and PETscans of the brain. The various forms of dementia have differing prognoses (expected outcome of illness), and also differing sets of epidemiologic risk factors. The causal etiology of many of them, including Alzheimer's disease, remains unclear, although many theories exist such as accumulation of protein plaques as part of normal aging, inflammation (either from bacterial pathogens or exposure to toxic chemicals), inadequate blood sugar, and traumatic brain injury.^{[citation needed]}

Society and culture

The societal cost of dementia is high, especially for family caregivers.^[147]

Many countries consider the care of people living with dementia a national priority and invest in resources and education to better inform health and social service workers, unpaid caregivers, relatives, and members of the wider community. Several countries have national plans or strategies.^[148]^[149] In these national plans, there is recognition that people can live well with dementia for a number of years, as long as there is the right support and timely access to a diagnosis. The former British Prime Minister David Cameron has described dementia as being a "national crisis", affecting 800,000 people in the United Kingdom.^[150]

In the United Kingdom, as with all mental disorders, where people with dementia could potentially be a danger to themselves or others, they can be detained under the Mental Health Act 1983 for the purposes of assessment, care and treatment. This is a last resort, and usually avoided if the person has family or friends who can ensure care.

Some hospitals in Britain are working to provide enriched and friendlier care. To make the hospital wards calmer and less overwhelming to the residents, the staff is replacing the usual nurses' station with a collection of smaller desks, similar to a receptionist's. The incorporation of bright lighting helps increase positive mood and allow for the residents to see more easily.^[151]

Driving with dementia could lead to severe injury or even death to self and others. Doctors should advise appropriate testing on when to quit driving.^[152] The United Kingdom DVLA (Driver & Vehicle Licensing Agency) states that people with dementia who specifically have poor short term memory, disorientation, or lack of insight or judgment are not fit to drive, and in these instances the DVLA must be informed so that the driving licence can be revoked. They do, however, acknowledge low-severity cases and those with an early diagnosis, and those drivers may be permitted to drive pending medical reports.

Many support networks are available to people with dementia and their families and caregivers. Several charitable organisations aim to raise awareness and campaign for the rights of people living with dementia. There is also support and guidance on assessing testamentary capacity in people who have dementia.^[153]

In 2015, Atlantic Philanthropies announced a $177 million gift aimed at understanding and reducing dementia. The recipient was Global Brain Health Institute, a program co-led by the University of California, San Francisco and Trinity College Dublin. This donation is the largest non-capital grant Atlantic has ever made, and the biggest philanthropic donation in Irish history.^[154]

Dental health

There is limited evidence that links poor oral health to cognitive decline. However, failure to perform tooth brushing and gingival inflammation can be used as dementia risk predictors.^[155]

Oral bacteria

The link between Alzheimer's and gum disease is oral bacteria.^[156] In the oral cavity, a large number of bacterial species can be found including P. gingivalis, F. nucleatum, P. intermedia, and T. forsythia. Six oral trepomena spirochetes have also been examined in the brains of Alzheimer's patients.^[157] Spirochetes are neurotropic in nature, meaning they act to destroy nerve tissue and create inflammation. Inflammatory pathogens are an indicator of Alzheimer's disease and bacteria related to gum disease have been found in the brains of Alzheimer's disease individuals.^[157] The bacteria invade nerve tissue in the brain, increasing the permeability of the blood-brain barrier and promoting the onset of Alzheimer's among the elderly population. It has also been found that individuals with a plethora of tooth plaque have a risk of cognitive decline.^[158] Poor oral hygiene can also have an adverse effect on speech and nutrition causing general and cognitive health decline.

Oral viruses

Herpes simplex virus (HSV) has been found in over 70% of the 50 and older population. HSV persists in the peripheral nervous system and can be triggered by stress, illness or fatigue.^[157] High proportions of viral-associated proteins in amyloid-containing plaques or neurofibrillary tangles (NFTs) highly confirm the involvement of HSV-1 in Alzheimer's disease pathology. NFTs are known as the primary marker of Alzheimer's disease. HSV-1 produces the main components of NFTs.^[159]

References

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External links

Media related to Dementia at Wikimedia Commons

Dementia at Curlie

Template:Speech and voice symptoms and signs

[senility-1] "Dementia". MedlinePlus. U.S. National Library of Medicine. 14 May 2015. Archived from the original on 12 May 2015. Retrieved 6 August 2018. Dementia Also called: Senility {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)

[WHO2014-2] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r ^s ^t ^u "Dementia Fact sheet N°362". who.int. April 2012. Archived from the original on 18 March 2015. Retrieved 28 November 2014. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)

[BMJ2009-3] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j Burns A, Iliffe S (February 2009). "Dementia". BMJ. 338: b75. doi:10.1136/bmj.b75. PMID 19196746.

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[5] Hales, Robert E. (2008). The American Psychiatric Publishing Textbook of Psychiatry. American Psychiatric Pub. p. 311. ISBN 978-1585622573. Archived from the original on 2017-09-08. {{cite book}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)

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[Memory_Loss-11] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ ^o ^p ^q ^r ^s ^t ^u ^v Budson, Andrew; Solomon, Paul (2011). Memory loss : a practical guide for clinicians. [Edinburgh?]: Elsevier Saunders. ISBN 978-1416035978. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

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[senility-mednet-144] Taylor, Danette C. "Dementia". MedicineNet. Retrieved 6 August 2018. Senile dementia ("senility") is a term that was once used to describe all dementias; this term is no longer used as a diagnosis.

[145] Kolata, Gina (June 17, 2010). "Drug Trials Test Bold Plan to Slow Alzheimer's". The New York Times. Archived from the original on April 9, 2012. Retrieved June 17, 2010. {{cite news}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help); Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

[Katzman1976-146] Katzman R (April 1976). "Editorial: The prevalence and malignancy of Alzheimer disease. A major killer". Archives of Neurology. 33 (4): 217–18. doi:10.1001/archneur.1976.00500040001001. PMID 1259639.

[147] Brodaty H, Donkin M (29 April 2017). "Family caregivers of people with dementia". Dialogues in Clinical Neuroscience. 11 (2): 217–28. PMC 3181916. PMID 19585957.

[148] "National Alzheimer and Dementia Plans Planned Policies and Activities (PDF)" (PDF). London: Alzheimer's Disease International. April 2012. Archived from the original (PDF) on 2012-05-18. {{cite news}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)

[149] "Addressing Alzheimer's and Other Types of Dementia:Israeli National Strategy Summary Document of the Interdisciplinary, Inter-Organizational Group of Experts » Brookdale". Brookdale. Retrieved 2018-06-04.

[150] Boseley, Sarah (26 March 2012). "Dementia research funding to more than double to £66m by 2015". The Guardian. London. ISSN 0261-3077. OCLC 60623878. Archived from the original on 20 October 2013. Retrieved 27 April 2012. {{cite news}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help); Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

[151] "British hospitals are having a dementia-friendly makeover". The Economist. Retrieved 2018-09-17.

[152] "Drivers with dementia a growing problem, MDs warn". CBC News, Canada. September 19, 2007. Archived from the original on October 2, 2007. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)

[153] Thompson SB (2009). "Testamentary capacity and cognitive rehabilitation: implications for head-injured and neurologically impaired individuals". Journal of Cognitive Rehabilitation. 27: 11–13.

[154] "Tackling dementia". Philanthropy magazine. Winter 2016. Archived from the original on 2016-02-11. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)

[155] Daly B, Thompsell A, Sharpling J, Rooney YM, Hillman L, Wanyonyi KL, White S, Gallagher JE (January 2018). "Evidence summary: the relationship between oral health and dementia". British Dental Journal. 223 (11): 846–53. doi:10.1038/sj.bdj.2017.992. PMID 29192686. Archived from the original on 2018-05-09. {{cite journal}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)

[Miklossy-156] Miklossy, J (2015). "Historic evidence to support a causal relationship between spirochetal infections and Alzheimer's disease". Frontiers in Aging Neuroscience. 7: 46. doi:10.3389/fnagi.2015.00046. PMC 4399390. PMID 25932012.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[Olsen_2015-157] Olsen I, Singhrao SK (2015-09-17). "Can oral infection be a risk factor for Alzheimer's disease?". Journal of Oral Microbiology. 7: 29143. doi:10.3402/jom.v7.29143. PMC 4575419. PMID 26385886.

[BDJ_2017-158] "Can poor oral health lead to dementia?". British Dental Journal. 223 (11): 840. December 2017. doi:10.1038/sj.bdj.2017.1064. PMID 29243693.

[159] Carter CJ (February 2011). "Alzheimer's disease plaques and tangles: cemeteries of a pyrrhic victory of the immune defence network against herpes simplex infection at the expense of complement and inflammation-mediated neuronal destruction". Neurochemistry International. 58 (3): 301–20. doi:10.1016/j.neuint.2010.12.003. PMID 21167244.

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@@ Line 9: / Line 9: @@
 | field           = [[Neurology]], [[psychiatry]]
 | symptoms        = Decreased ability to [[think]] and remember, emotional problems, problems with [[language]], decreased [[motivation]]<ref name=WHO2014/><ref name=BMJ2009/>
 | complications   =
 | onset           = Gradual<ref name=WHO2014/>
 | duration        = Long term<ref name=WHO2014/>
 | causes          = [[Alzheimer's disease]], [[vascular dementia]], [[Dementia with Lewy bodies|Lewy body dementia]], [[frontotemporal dementia]]<ref name=WHO2014/><ref name=BMJ2009/>
 | risks           =
 | diagnosis       = [[Cognitive testing]] ([[mini mental state examination]])<ref name=BMJ2009/><ref name=NICE2014Diag/>
-| differential    = [[Delirium]]<ref>{{cite book|last1=Hales|first1=Robert E.|title=The American Psychiatric Publishing Textbook of Psychiatry|date=2008|publisher=American Psychiatric Pub|isbn=978-1-58562-257-3|page=311|url=https://books.google.com/books?id=2RzFWRIAsPAC&pg=PA311|language=en|deadurl=no|archive-url=https://web.archive.org/web/20170908004600/https://books.google.com/books?id=2RzFWRIAsPAC&pg=PA311|archive-date=2017-09-08}}</ref>
+| differential    = [[Delirium]]<ref>{{cite book|last1=Hales|first1=Robert E.|title=The American Psychiatric Publishing Textbook of Psychiatry|date=2008|publisher=American Psychiatric Pub|isbn=978-1585622573|page=311|url=https://books.google.com/books?id=2RzFWRIAsPAC&pg=PA311|language=en|deadurl=no|archive-url=https://web.archive.org/web/20170908004600/https://books.google.com/books?id=2RzFWRIAsPAC&pg=PA311|archive-date=2017-09-08}}</ref>
 | prevention      = Early education, prevent high blood pressure, prevent [[obesity]], no smoking, exercise, social engagement<ref name=Liv2017/>
 | treatment       = [[Supportive care]]<ref name=WHO2014/>
-| medication      = [[Acetylcholinesterase inhibitor|Cholinesterase inhibitor]]s (small benefit)<ref name=Kav2007/><ref name=Comm2012/>
+| medication      = [[Acetylcholinesterase inhibitor|Cholinesterase inhibitors]] (small benefit)<ref name=Kav2007/><ref name=Comm2012/>
 | prognosis       =
 | frequency       = 46 million (2015)<ref name=GBD2015Pre>{{cite journal | author = GBD 2015 Disease and Injury Incidence and Prevalence Collaborators | title = Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015 | journal = Lancet | volume = 388 | issue = 10053 | pages = 1545–1602 | date = October 2016 | pmid = 27733282 | pmc = 5055577 | doi = 10.1016/S0140-6736(16)31678-6 }}</ref>
 | deaths          = 1.9 million (2015)<ref name=GBD2015De>{{cite journal | author = GBD 2015 Mortality and Causes of Death Collaborators | title = Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015 | journal = Lancet | volume = 388 | issue = 10053 | pages = 1459–1544 | date = October 2016 | pmid = 27733281 | pmc = 5388903 | doi = 10.1016/s0140-6736(16)31012-1 }}</ref>
@@ Line 25: / Line 25: @@
 <!-- Definition and symptoms -->
-'''Dementia''' is a broad category of [[neurological disorder|brain diseases]] that cause a long-term and often gradual decrease in the ability to [[Thought|think]] and remember that is great enough to affect a person's daily functioning.<ref name="WHO2014">{{cite web|title=Dementia  Fact sheet N°362|url=http://www.who.int/mediacentre/factsheets/fs362/en/|website=who.int|access-date=28 November 2014|date=April 2012|deadurl=yes|archive-url=https://web.archive.org/web/20150318030901/http://www.who.int/mediacentre/factsheets/fs362/en|archive-date=18 March 2015}}</ref> Other common [[symptoms]] include emotional problems, difficulties with language, and a [[aboulia|decrease in motivation]].<ref name="WHO2014" /><ref name="BMJ2009">{{cite journal | vauthors = Burns A, Iliffe S | title = Dementia | journal = BMJ | volume = 338 | pages = b75 | date = February 2009 | pmid = 19196746 | doi = 10.1136/bmj.b75 }}</ref> A person's [[consciousness]] is usually not affected.<ref name="WHO2014" /> A dementia diagnosis requires a change from a person's usual mental functioning and a greater decline than one would expect due to [[Ageing|aging]].<ref name=WHO2014/><ref name="Memory Loss">{{cite book | first1 = Andrew | last1 = Budson | first2 = Paul | last2 = Solomon | name-list-format = vanc |title=Memory loss : a practical guide for clinicians|year=2011|publisher=Elsevier Saunders|location=[Edinburgh?]|isbn=978-1-4160-3597-8|url=https://books.google.com/?id=48HAK0HOF6cC&pg=PR10#v=onepage&q&f=false}}</ref> These diseases also have a significant effect on a person's [[caregiver]]s.<ref name="WHO2014" />
+'''Dementia''' is a broad category of [[neurological disorder|brain diseases]] that cause a long-term and often gradual decrease in the ability to [[Thought|think]] and remember that is great enough to affect a person's daily functioning.<ref name="WHO2014">{{cite web|title=Dementia  Fact sheet N°362|url=http://www.who.int/mediacentre/factsheets/fs362/en/|website=who.int|access-date=28 November 2014|date=April 2012|deadurl=yes|archive-url=https://web.archive.org/web/20150318030901/http://www.who.int/mediacentre/factsheets/fs362/en|archive-date=18 March 2015}}</ref> Other common [[symptoms]] include emotional problems, difficulties with language, and a [[aboulia|decrease in motivation]].<ref name="WHO2014" /><ref name="BMJ2009">{{cite journal | vauthors = Burns A, Iliffe S | title = Dementia | journal = BMJ | volume = 338 | pages = b75 | date = February 2009 | pmid = 19196746 | doi = 10.1136/bmj.b75 }}</ref> A person's [[consciousness]] is usually not affected.<ref name="WHO2014" /> A dementia diagnosis requires a change from a person's usual mental functioning and a greater decline than one would expect due to [[Ageing|aging]].<ref name=WHO2014/><ref name="Memory Loss">{{cite book | first1 = Andrew | last1 = Budson | first2 = Paul | last2 = Solomon | name-list-format = vanc |title=Memory loss : a practical guide for clinicians|year=2011|publisher=Elsevier Saunders|location=[Edinburgh?]|isbn=978-1416035978|url=https://books.google.com/?id=48HAK0HOF6cC&pg=PR10#v=onepage&q&f=false}}</ref> These diseases also have a significant effect on a person's [[caregiver]]s.<ref name="WHO2014" />
 <!-- Cause, diagnosis, prevention -->
-The most common type of dementia is [[Alzheimer's disease]], which makes up 50% to 70% of cases.<ref name=WHO2014/><ref name=BMJ2009/> Other common types include [[vascular dementia]] (25%), [[Dementia with Lewy bodies|Lewy body dementia]] (15%), and [[frontotemporal dementia]].<ref name=WHO2014/><ref name=BMJ2009/> Less common causes include [[normal pressure hydrocephalus]], [[Parkinson's disease dementia]], [[syphilis]], and [[Creutzfeldt–Jakob disease]] among others.<ref>{{cite book | last1 = Gauthier | first1 = Serge | name-list-format = vanc | title = Clinical diagnosis and management of Alzheimer's disease | date = 2006 | publisher = Informa Healthcare | location = Abingdon, Oxon | isbn = 978-0-203-93171-4 | pages = 53–54 | edition = 3rd | url = https://books.google.com/books?id=a221hX4WuwUC&pg=PA54|deadurl=no|archive-url=https://web.archive.org/web/20160503111047/https://books.google.com/books?id=a221hX4WuwUC&pg=PA54|archive-date=2016-05-03}}</ref> More than one type of dementia may exist in the same person.<ref name=WHO2014/> A small proportion of cases run in families.<ref name=Genetic2014/> In the [[DSM-5]], dementia was reclassified as a [[DSM-5#Neurocognitive disorders|neurocognitive disorder]], with various degrees of severity.<ref name=DSM5>{{cite book|last1=Association|first1=American Psychiatric|title=Diagnostic and statistical manual of mental disorders : DSM-5.|date=2013|publisher=American Psychiatric Association|location=Washington, D.C.|isbn=978-0-89042-554-1|pages=591–603|edition=5th}}</ref> Diagnosis is usually based on history of the illness and [[cognitive testing]] with [[medical imaging]] and [[blood test]]s used to rule out other possible causes.<ref name=NICE2014Diag>{{cite web|title=Dementia diagnosis and assessment|url=http://pathways.nice.org.uk/pathways/dementia/dementia-diagnosis-and-assessment.pdf|website=pathways.nice.org.uk|access-date=30 November 2014|deadurl=yes|archive-url=https://web.archive.org/web/20141205184403/http://pathways.nice.org.uk/pathways/dementia/dementia-diagnosis-and-assessment.pdf|archive-date=5 December 2014|df=dmy-all}}</ref> The [[mini mental state examination]] is one commonly used [[cognitive test]].<ref name=BMJ2009/> Efforts to prevent dementia include trying to decrease [[risk factor]]s such as [[hypertension|high blood pressure]], [[smoking]], [[diabetes mellitus|diabetes]], and [[obesity]].<ref name=WHO2014/> Screening the general population for the disorder is not recommended.<ref name=NICE2014>{{cite web|title=Dementia overview|url=http://pathways.nice.org.uk/pathways/dementia/dementia-overview.pdf|website=pathways.nice.org.uk|access-date=30 November 2014|deadurl=no|archive-url=https://web.archive.org/web/20141205184234/http://pathways.nice.org.uk/pathways/dementia/dementia-overview.pdf|archive-date=5 December 2014}}</ref>
+The most common type of dementia is [[Alzheimer's disease]], which makes up 50% to 70% of cases.<ref name=WHO2014/><ref name=BMJ2009/> Other common types include [[vascular dementia]] (25%), [[Dementia with Lewy bodies|Lewy body dementia]] (15%), and [[frontotemporal dementia]].<ref name=WHO2014/><ref name=BMJ2009/> Less common causes include [[normal pressure hydrocephalus]], [[Parkinson's disease dementia]], [[syphilis]], and [[Creutzfeldt–Jakob disease]] among others.<ref>{{cite book | last1 = Gauthier | first1 = Serge | name-list-format = vanc | title = Clinical diagnosis and management of Alzheimer's disease | date = 2006 | publisher = Informa Healthcare | location = Abingdon, Oxon | isbn = 978-0203931714 | pages = 53–54 | edition = 3rd | url = https://books.google.com/books?id=a221hX4WuwUC&pg=PA54|deadurl=no|archive-url=https://web.archive.org/web/20160503111047/https://books.google.com/books?id=a221hX4WuwUC&pg=PA54|archive-date=2016-05-03}}</ref> More than one type of dementia may exist in the same person.<ref name=WHO2014/> A small proportion of cases run in families.<ref name=Genetic2014/> In the [[DSM-5]], dementia was reclassified as a [[DSM-5#Neurocognitive disorders|neurocognitive disorder]], with various degrees of severity.<ref name=DSM5>{{cite book|last1=Association|first1=American Psychiatric|title=Diagnostic and statistical manual of mental disorders : DSM-5.|date=2013|publisher=American Psychiatric Association|location=Washington, DC|isbn=978-0890425541|pages=591–603|edition=5th}}</ref> Diagnosis is usually based on history of the illness and [[cognitive testing]] with [[medical imaging]] and [[blood test]]s used to rule out other possible causes.<ref name=NICE2014Diag>{{cite web|title=Dementia diagnosis and assessment|url=http://pathways.nice.org.uk/pathways/dementia/dementia-diagnosis-and-assessment.pdf|website=pathways.nice.org.uk|access-date=30 November 2014|deadurl=yes|archive-url=https://web.archive.org/web/20141205184403/http://pathways.nice.org.uk/pathways/dementia/dementia-diagnosis-and-assessment.pdf|archive-date=5 December 2014|df=dmy-all}}</ref> The [[mini mental state examination]] is one commonly used [[cognitive test]].<ref name=BMJ2009/> Efforts to prevent dementia include trying to decrease [[risk factor]]s such as [[hypertension|high blood pressure]], [[smoking]], [[diabetes mellitus|diabetes]], and [[obesity]].<ref name=WHO2014/> Screening the general population for the disorder is not recommended.<ref name=NICE2014>{{cite web|title=Dementia overview|url=http://pathways.nice.org.uk/pathways/dementia/dementia-overview.pdf|website=pathways.nice.org.uk|access-date=30 November 2014|deadurl=no|archive-url=https://web.archive.org/web/20141205184234/http://pathways.nice.org.uk/pathways/dementia/dementia-overview.pdf|archive-date=5 December 2014}}</ref>
 <!-- Management -->
-There is no known [[cure]] for dementia.<ref name=WHO2014/> [[Acetylcholinesterase inhibitor|Cholinesterase inhibitor]]s such as [[donepezil]] are often used and may be beneficial in mild to moderate disorder.<ref name=Kav2007>{{cite journal | vauthors = Kavirajan H, Schneider LS | title = Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials | journal = The Lancet. Neurology | volume = 6 | issue = 9 | pages = 782–92 | date = September 2007 | pmid = 17689146 | doi = 10.1016/s1474-4422(07)70195-3 }}</ref><ref name=Bir2006>{{cite journal | vauthors = Birks J | title = Cholinesterase inhibitors for Alzheimer's disease | journal = The Cochrane Database of Systematic Reviews | issue = 1 | pages = CD005593 | date = January 2006 | pmid = 16437532 | doi = 10.1002/14651858.CD005593 }}</ref><ref>{{cite journal | vauthors = Rolinski M, Fox C, Maidment I, McShane R | title = Cholinesterase inhibitors for dementia with Lewy bodies, Parkinson's disease dementia and cognitive impairment in Parkinson's disease | journal = The Cochrane Database of Systematic Reviews | volume = 3 | issue = 3 | pages = CD006504 | date = March 2012 | pmid = 22419314 | doi = 10.1002/14651858.CD006504.pub2 }}</ref> Overall benefit, however, may be minor.<ref name=Kav2007/><ref name=Comm2012>{{cite journal | author = Commission de la transparence | title = Drugs for Alzheimer's disease: best avoided. No therapeutic advantage | journal = Prescrire International | volume = 21 | issue = 128 | pages = 150 | date = June 2012 | pmid = 22822592 | doi =  | trans-title = Drugs for Alzheimer's disease: best avoided. No therapeutic advantage }}</ref> There are many measures that can improve the quality of life of people with dementia and their caregivers.<ref name=WHO2014/> [[Cognitive behavioral therapy|Cognitive and behavioral interventions]] may be appropriate.<ref name=WHO2014/> Educating and providing emotional support to the [[caregiver]] is important.<ref name=WHO2014/> Exercise programs may be beneficial with respect to [[activities of daily living]] and potentially improve outcomes.<ref name=Forb2015>{{cite journal | vauthors = Forbes D, Forbes SC, Blake CM, Thiessen EJ, Forbes S | title = Exercise programs for people with dementia | journal = The Cochrane Database of Systematic Reviews | volume = 132 | issue = 4 | pages = 195–196 | date = April 2015 | pmid = 25874613 | doi = 10.1002/14651858.CD006489.pub4 | url = http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802014000300195 | type = Submitted manuscript }}</ref> Treatment of behavioral problems with [[antipsychotic]]s is common but not usually recommended due to the little benefit and side effects, including an increased risk of [[death]].<ref>{{cite web|author1=National Institute for Health and Clinical Excellence |title=Low-dose antipsychotics in people with dementia |url=https://www.nice.org.uk/advice/ktt7/resources/non-guidance-lowdose-antipsychotics-in-people-with-dementia-pdf |website=nice.org.uk |access-date=29 November 2014 |deadurl=yes |archive-url=https://web.archive.org/web/20141205183329/https://www.nice.org.uk/advice/ktt7/resources/non-guidance-lowdose-antipsychotics-in-people-with-dementia-pdf |archive-date=5 December 2014 |df= }}</ref><ref>{{cite web|title=Information for Healthcare Professionals: Conventional Antipsychotics|url=http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm124830.htm|website=fda.gov|access-date=29 November 2014|date=2008-06-16|deadurl=no|archive-url=https://web.archive.org/web/20141129015823/http://www.fda.gov/drugs/drugsafety/postmarketdrugsafetyinformationforpatientsandproviders/ucm124830.htm|archive-date=29 November 2014}}</ref>
+There is no known [[cure]] for dementia.<ref name=WHO2014/> [[Acetylcholinesterase inhibitor|Cholinesterase inhibitors]] such as [[donepezil]] are often used and may be beneficial in mild to moderate disorder.<ref name=Kav2007>{{cite journal | vauthors = Kavirajan H, Schneider LS | title = Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials | journal = The Lancet. Neurology | volume = 6 | issue = 9 | pages = 782–92 | date = September 2007 | pmid = 17689146 | doi = 10.1016/s1474-4422(07)70195-3 }}</ref><ref name=Bir2006>{{cite journal | vauthors = Birks J | title = Cholinesterase inhibitors for Alzheimer's disease | journal = The Cochrane Database of Systematic Reviews | issue = 1 | pages = CD005593 | date = January 2006 | pmid = 16437532 | doi = 10.1002/14651858.CD005593 }}</ref><ref>{{cite journal | vauthors = Rolinski M, Fox C, Maidment I, McShane R | title = Cholinesterase inhibitors for dementia with Lewy bodies, Parkinson's disease dementia and cognitive impairment in Parkinson's disease | journal = The Cochrane Database of Systematic Reviews | volume = 3 | issue = 3 | pages = CD006504 | date = March 2012 | pmid = 22419314 | doi = 10.1002/14651858.CD006504.pub2 }}</ref> Overall benefit, however, may be minor.<ref name=Kav2007/><ref name=Comm2012>{{cite journal | author = Commission de la transparence | title = Drugs for Alzheimer's disease: best avoided. No therapeutic advantage | journal = Prescrire International | volume = 21 | issue = 128 | pages = 150 | date = June 2012 | pmid = 22822592 | doi =  | trans-title = Drugs for Alzheimer's disease: best avoided. No therapeutic advantage }}</ref> There are many measures that can improve the quality of life of people with dementia and their caregivers.<ref name=WHO2014/> [[Cognitive behavioral therapy|Cognitive and behavioral interventions]] may be appropriate.<ref name=WHO2014/> Educating and providing emotional support to the [[caregiver]] is important.<ref name=WHO2014/> Exercise programs may be beneficial with respect to [[activities of daily living]] and potentially improve outcomes.<ref name=Forb2015>{{cite journal | vauthors = Forbes D, Forbes SC, Blake CM, Thiessen EJ, Forbes S | title = Exercise programs for people with dementia | journal = The Cochrane Database of Systematic Reviews | volume = 132 | issue = 4 | pages = 195–96 | date = April 2015 | pmid = 25874613 | doi = 10.1002/14651858.CD006489.pub4 | url = http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802014000300195 | type = Submitted manuscript }}</ref> Treatment of behavioral problems with [[antipsychotic]]s is common but not usually recommended due to the little benefit and side effects, including an increased risk of [[death]].<ref>{{cite web|author1=National Institute for Health and Clinical Excellence |title=Low-dose antipsychotics in people with dementia |url=https://www.nice.org.uk/advice/ktt7/resources/non-guidance-lowdose-antipsychotics-in-people-with-dementia-pdf |website=nice.org.uk |access-date=29 November 2014 |deadurl=yes |archive-url=https://web.archive.org/web/20141205183329/https://www.nice.org.uk/advice/ktt7/resources/non-guidance-lowdose-antipsychotics-in-people-with-dementia-pdf |archive-date=5 December 2014 |df= }}</ref><ref>{{cite web|title=Information for Healthcare Professionals: Conventional Antipsychotics|url=http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm124830.htm|website=fda.gov|access-date=29 November 2014|date=2008-06-16|deadurl=no|archive-url=https://web.archive.org/web/20141129015823/http://www.fda.gov/drugs/drugsafety/postmarketdrugsafetyinformationforpatientsandproviders/ucm124830.htm|archive-date=29 November 2014}}</ref>
 <!-- Epidemiology, prognosis, and society -->
-Globally, dementia affected about 46 million people in 2015.<ref name=GBD2015Pre/> About 10% of people develop the disorder at some point in their lives.<ref name=Genetic2014>{{cite journal | vauthors = Loy CT, Schofield PR, Turner AM, Kwok JB | title = Genetics of dementia | journal = Lancet | volume = 383 | issue = 9919 | pages = 828–40 | date = March 2014 | pmid = 23927914 | doi = 10.1016/s0140-6736(13)60630-3 }}</ref> It becomes more common with age.<ref name=Larson2013>{{cite journal | vauthors = Larson EB, Yaffe K, Langa KM | title = New insights into the dementia epidemic | journal = The New England Journal of Medicine | volume = 369 | issue = 24 | pages = 2275–7 | date = December 2013 | pmid = 24283198 | pmc = 4130738 | doi = 10.1056/nejmp1311405 }}</ref> About 3% of people between the ages of 65–74 have dementia, 19% between 75 and 84, and nearly half of those over 85 years of age.<ref>{{cite book|last1=Umphred|first1=Darcy|title=Neurological rehabilitation|date=2012|publisher=Elsevier Mosby|location=St. Louis, Mo.|isbn=978-0-323-07586-2|page=838|edition=6th|url=https://books.google.com/books?id=I9ltC-ZrNOMC&pg=PA838 | deadurl = no | archive-url = https://web.archive.org/web/20160422135922/https://books.google.com/books?id=I9ltC-ZrNOMC&pg=PA838 | archive-date = 2016-04-22}}</ref> In 2013 dementia resulted in about 1.7 million deaths up from 0.8 million in 1990.<ref name=GDB2013>{{cite journal | author = GBD 2013 Mortality and Causes of Death Collaborators | title = Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013 | journal = Lancet | volume = 385 | issue = 9963 | pages = 117–71 | date = January 2015 | pmid = 25530442 | pmc = 4340604 | doi = 10.1016/S0140-6736(14)61682-2 }}</ref> As more people are living longer, dementia is becoming more common in the population as a whole.<ref name=Larson2013/> For people of a specific age, however, it may be becoming less frequent, at least in the developed world, due to a decrease in risk factors.<ref name=Larson2013/> It is one of the most common causes of [[disability]] among the old.<ref name=BMJ2009/> It is believed to result in economic costs of US$604 billion a year.<ref name=WHO2014/> People with dementia are often physically or [[chemically restrained]] to a greater degree than necessary, raising issues of [[human rights]].<ref name=WHO2014/> [[Social stigma]] against those affected is common.<ref name=BMJ2009/>
+Globally, dementia affected about 46 million people in 2015.<ref name=GBD2015Pre/> About 10% of people develop the disorder at some point in their lives.<ref name=Genetic2014>{{cite journal | vauthors = Loy CT, Schofield PR, Turner AM, Kwok JB | title = Genetics of dementia | journal = Lancet | volume = 383 | issue = 9919 | pages = 828–40 | date = March 2014 | pmid = 23927914 | doi = 10.1016/s0140-6736(13)60630-3 }}</ref> It becomes more common with age.<ref name=Larson2013>{{cite journal | vauthors = Larson EB, Yaffe K, Langa KM | title = New insights into the dementia epidemic | journal = The New England Journal of Medicine | volume = 369 | issue = 24 | pages = 2275–77 | date = December 2013 | pmid = 24283198 | pmc = 4130738 | doi = 10.1056/nejmp1311405 }}</ref> About 3% of people between the ages of 65–74 have dementia, 19% between 75 and 84, and nearly half of those over 85 years of age.<ref>{{cite book|last1=Umphred|first1=Darcy|title=Neurological rehabilitation|date=2012|publisher=Elsevier Mosby|location=St. Louis, MO|isbn=978-0323075862|page=838|edition=6th|url=https://books.google.com/books?id=I9ltC-ZrNOMC&pg=PA838 | deadurl = no | archive-url = https://web.archive.org/web/20160422135922/https://books.google.com/books?id=I9ltC-ZrNOMC&pg=PA838 | archive-date = 2016-04-22}}</ref> In 2013 dementia resulted in about 1.7 million deaths up from 0.8 million in 1990.<ref name=GDB2013>{{cite journal | author = GBD 2013 Mortality and Causes of Death Collaborators | title = Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013 | journal = Lancet | volume = 385 | issue = 9963 | pages = 117–71 | date = January 2015 | pmid = 25530442 | pmc = 4340604 | doi = 10.1016/S0140-6736(14)61682-2 }}</ref> As more people are living longer, dementia is becoming more common in the population as a whole.<ref name=Larson2013/> For people of a specific age, however, it may be becoming less frequent, at least in the developed world, due to a decrease in risk factors.<ref name=Larson2013/> It is one of the most common causes of [[disability]] among the old.<ref name=BMJ2009/> It is believed to result in economic costs of US$604 billion a year.<ref name=WHO2014/> People with dementia are often physically or [[chemically restrained]] to a greater degree than necessary, raising issues of [[human rights]].<ref name=WHO2014/> [[Social stigma]] against those affected is common.<ref name=BMJ2009/>
 == Signs and symptoms ==
@@ Line 42: / Line 42: @@
 The symptoms of dementia vary across types and stages of the [[diagnosis]].<ref>{{cite web|title=Dementia – Signs and Symptoms|publisher= American Speech Language Hearing Association|url=http://www.asha.org/PRPSpecificTopic.aspx?folderid=8589935289&section=Signs_and_Symptoms}}</ref> The most common affected areas include [[memory]], [[Spatial visualization ability|visual-spatial]], [[language]], [[attention]] and [[problem solving]]. Most types of dementia are slow and progressive. By the time the person shows signs of the disorder, the process in the brain has been happening for a long time. It is possible for a patient to have two types of dementia at the same time. About 10% of people with dementia have what is known as ''mixed dementia'', which is usually a combination of Alzheimer's disease and another type of dementia such as [[frontotemporal dementia]] or [[vascular dementia]].<ref>[http://www.alzheimers.org.uk/site/scripts/documents_info.php?categoryID=200171&documentID=161&gclid=CNfxysiaxK4CFeYhtAodDlEIXQ What is vascular dementia?] {{webarchive|url=https://web.archive.org/web/20131019172030/http://www.alzheimers.org.uk/site/scripts/documents_info.php?categoryID=200171&documentID=161&gclid=CNfxysiaxK4CFeYhtAodDlEIXQ |date=2013-10-19 }} Alzheimer's Society.</ref><ref>{{cite journal | vauthors = Lee AY | title = Vascular dementia | journal = Chonnam Medical Journal | volume = 47 | issue = 2 | pages = 66–71 | date = August 2011 | pmid = 22111063 | pmc = 3214877 | doi = 10.4068/cmj.2011.47.2.66 }}</ref>
-[[Neuropsychiatry|Neuropsychiatric]] symptoms that may be present are termed ''Behavioural and psychological symptoms of dementia'' (BPSD) and these can include:<ref name="Sahin">{{cite journal |last1=Şahin Cankurtaran |first1=E |title=Management of Behavioral and Psychological Symptoms of Dementia. |journal=Noro Psikiyatri Arsivi |date=December 2014 |volume=51 |issue=4 |pages=303–312 |doi=10.5152/npa.2014.7405 |pmid=28360647|pmc=5353163 }}</ref>
+[[Neuropsychiatry|Neuropsychiatric]] symptoms that may be present are termed ''Behavioural and psychological symptoms of dementia'' (BPSD) and these can include:<ref name="Sahin">{{cite journal |last1=Şahin Cankurtaran |first1=E |title=Management of Behavioral and Psychological Symptoms of Dementia. |journal=Noro Psikiyatri Arsivi |date=December 2014 |volume=51 |issue=4 |pages=303–12 |doi=10.5152/npa.2014.7405 |pmid=28360647|pmc=5353163 }}</ref>
 * Balance problems
 * [[Tremor]]
@@ Line 50: / Line 50: @@
 * Wandering or restlessness
 * Perception and visual problems<ref>{{cite news|title=Sight, perception and hallucinations in dementia|url=https://www.alzheimers.org.uk/download/downloads/id/3369/sight_perception_and_hallucinations_in_dementia.pdf|access-date=4 November 2015|publisher=Alzheimer's Society|date=October 2015|deadurl=no|archive-url=https://web.archive.org/web/20170813152246/https://www.alzheimers.org.uk/download/downloads/id/3369/sight_perception_and_hallucinations_in_dementia.pdf|archive-date=13 August 2017}}</ref>
-*{{anchor|BPSD}} Behavioral and psychological symptoms of dementia almost always occur in all types of dementia and may manifest as:<ref>{{cite journal | vauthors = Cerejeira J, Lagarto L, Mukaetova-Ladinska EB | title = Behavioral and psychological symptoms of dementia | journal = Frontiers in Neurology | volume = 3 | issue =  | pages = 73 | year = 2012 | pmid = 22586419 | pmc = 3345875 | doi = 10.3389/fneur.2012.00073 }}</ref><ref>{{cite journal |vauthors=Calleo J, Stanley M |title=Anxiety Disorders in Later Life Differentiated Diagnosis and Treatment Strategies |journal=Psychiatric Times |volume=25 |issue=8 |year=2008 |url=http://www.psychiatrictimes.com/display/article/10168/1166976 |deadurl=no |archive-url=https://web.archive.org/web/20090904032148/http://www.psychiatrictimes.com/display/article/10168/1166976 |archive-date=2009-09-04 |df= }}</ref>
+* {{anchor|BPSD}} Behavioral and psychological symptoms of dementia almost always occur in all types of dementia and may manifest as:<ref>{{cite journal | vauthors = Cerejeira J, Lagarto L, Mukaetova-Ladinska EB | title = Behavioral and psychological symptoms of dementia | journal = Frontiers in Neurology | volume = 3 | issue =  | pages = 73 | year = 2012 | pmid = 22586419 | pmc = 3345875 | doi = 10.3389/fneur.2012.00073 }}</ref><ref>{{cite journal |vauthors=Calleo J, Stanley M |title=Anxiety Disorders in Later Life Differentiated Diagnosis and Treatment Strategies |journal=Psychiatric Times |volume=25 |issue=8 |year=2008 |url=http://www.psychiatrictimes.com/display/article/10168/1166976 |deadurl=no |archive-url=https://web.archive.org/web/20090904032148/http://www.psychiatrictimes.com/display/article/10168/1166976 |archive-date=2009-09-04 |df= }}</ref>
 :* Agitation
 :* [[Depression (mood)|Depression]]
 :*[[Anxiety]]
 :*Abnormal motor behavior
 :*Elated mood
@@ Line 62: / Line 62: @@
 :*Changes in sleep or appetite.
-When people with dementia are put in circumstances beyond their abilities, there may be a sudden change to crying or anger (a ''"catastrophic reaction"'').<ref>{{cite book | last1 = Geddes | first1 = John | last2 = Gelder | first2 = Michael G. | last3 = Mayou | first3 = Richard | name-list-format = vanc | title = Psychiatry |publisher=Oxford University Press |location=Oxford [Oxfordshire] |year=2005 |page=141 |isbn=978-0-19-852863-0 |oclc=56348037 }}</ref>
+When people with dementia are put in circumstances beyond their abilities, there may be a sudden change to crying or anger (a ''"catastrophic reaction"'').<ref>{{cite book | last1 = Geddes | first1 = John | last2 = Gelder | first2 = Michael G. | last3 = Mayou | first3 = Richard | name-list-format = vanc | title = Psychiatry |publisher=Oxford University Press |location=Oxford [Oxfordshire] |year=2005 |page=141 |isbn=978-0198528630 |oclc=56348037 }}</ref>
 Psychosis (often delusions of persecution) and agitation/aggression also often accompany dementia.<ref>{{Cite journal |last=Shub |first=Denis |last2=Kunik |first2=Mark E | name-list-format = vanc |title=Psychiatric Comorbidity in Persons With Dementia: Assessment and Treatment Strategies |journal=Psychiatric Times |volume=26 |issue=4 |date=April 16, 2009 |url=http://www.psychiatrictimes.com/alzheimer-dementia/article/10168/1403050 |deadurl=no |archive-url=https://web.archive.org/web/20090427144308/http://www.psychiatrictimes.com/alzheimer-dementia/article/10168/1403050 |archive-date=April 27, 2009 }}</ref>
 === Mild cognitive impairment ===
-In the first stages of dementia, the signs and symptoms of the disorder may be subtle. Often, the early signs of dementia only become apparent when looking back in time. The earliest stage of dementia is called [[mild cognitive impairment]] (MCI). 70% of those diagnosed with MCI progress to dementia at some point.<ref name="Memory Loss" />  In MCI, changes in the person's brain have been happening for a long time, but the symptoms of the disorder are just beginning to show.  These problems, however, are not yet severe enough to affect the person's daily function.  If they do, it is considered dementia. A person with MCI scores between 27 and 30 on the [[Mini-Mental State Examination]] (MMSE), which is a normal score. They may have some memory trouble and trouble finding words, but they solve everyday problems and handle their own life affairs well.<ref name="hugo">{{cite journal |pmc=4104432|year=2014|last1=Hugo|first1=J.|title=Dementia and Cognitive Impairment: Epidemiology, Diagnosis, and Treatment|journal=Clinics in Geriatric Medicine|volume=30|issue=3|pages=421–442|last2=Ganguli|first2=M.|pmid=25037289|doi=10.1016/j.cger.2014.04.001}}</ref>
+In the first stages of dementia, the signs and symptoms of the disorder may be subtle. Often, the early signs of dementia only become apparent when looking back in time. The earliest stage of dementia is called [[mild cognitive impairment]] (MCI). 70% of those diagnosed with MCI progress to dementia at some point.<ref name="Memory Loss" />  In MCI, changes in the person's brain have been happening for a long time, but the symptoms of the disorder are just beginning to show.  These problems, however, are not yet severe enough to affect the person's daily function.  If they do, it is considered dementia. A person with MCI scores between 27 and 30 on the [[Mini-Mental State Examination]] (MMSE), which is a normal score. They may have some memory trouble and trouble finding words, but they solve everyday problems and handle their own life affairs well.<ref name="hugo">{{cite journal |pmc=4104432|year=2014|last1=Hugo|first1=J.|title=Dementia and Cognitive Impairment: Epidemiology, Diagnosis, and Treatment|journal=Clinics in Geriatric Medicine|volume=30|issue=3|pages=421–42|last2=Ganguli|first2=M.|pmid=25037289|doi=10.1016/j.cger.2014.04.001}}</ref>
 === Early stages ===
 {{refimprove section|date=November 2015}}
-In the early stage of dementia, the person begins to show symptoms noticeable to the people around them. In addition, the symptoms begin to interfere with daily activities. The person usually scores between a 20 and 25 on the [[Mini–Mental State Examination|MMSE]]. The symptoms are dependent on the type of dementia a person has.  The person may begin to have difficulty with more complicated chores and tasks around the house or at work. The person can usually still take care of him or herself but may forget things like taking pills or doing laundry and may need prompting or reminders.<ref>{{Cite book|title=Dementia care at a glance|last=1960-|first=Jenkins, Catharine|others=Ginesi, Laura, 1956-, Keenan, Bernie, 1957-|isbn=9781118859988|location=Chichester, West Sussex, UK|oclc=905089525|date = 2016-01-26}}</ref>
+In the early stage of dementia, the person begins to show symptoms noticeable to the people around them. In addition, the symptoms begin to interfere with daily activities. The person usually scores between a 20 and 25 on the [[Mini–Mental State Examination|MMSE]]. The symptoms are dependent on the type of dementia a person has.  The person may begin to have difficulty with more complicated chores and tasks around the house or at work. The person can usually still take care of him or herself but may forget things like taking pills or doing laundry and may need prompting or reminders.<ref>{{Cite book|title=Dementia care at a glance|last=1960-|first=Jenkins, Catharine|others=Ginesi, Laura; Keenan, Bernie|isbn=978-1118859988|location=Chichester, West Sussex|oclc=905089525|date = 2016-01-26}}</ref>
 The symptoms of early dementia usually include memory difficulty, but can also include some word-finding problems (anomia) and problems with planning and organizational skills (executive function). One very good way of assessing a person's impairment is by asking if they are still able to handle their finances independently. This is often one of the first things to become problematic. Other signs might be getting lost in new places, repeating things, personality changes, social withdrawal and difficulties at work.
@@ Line 85: / Line 85: @@
 People with late-stage dementia typically turn increasingly inward and need assistance with most or all of their personal care. Persons with dementia in the late stages usually need 24-hour supervision to ensure personal safety, as well as to ensure that basic needs are being met.  If left unsupervised, a person with late-stage dementia may wander or fall, may not recognize common dangers around them such as a hot stove, may not realize that they need to use the bathroom or become unable to control their bladder or bowels (incontinent).<ref name=hugo/>
-Changes in eating frequently occur. Caregivers of people with late-stage dementia often provide [[Purée|pureed diets]], thickened liquids, and assistance in eating, to prolong their lives, to cause them to gain weight, to reduce the risk of choking, and to make feeding the person easier.<ref>{{Cite book|url=https://books.google.com/books?id=vc_FmgEACAAJ|title=How We Die Now: Intimacy and the Work of Dying|last=Erickson|first=Karla | name-list-format = vanc |date=2013-09-27|publisher=Temple University Press|isbn=9781439908235|pages=109–111|language=en|deadurl=no|archive-url=https://web.archive.org/web/20161223191201/https://books.google.com/books?id=vc_FmgEACAAJ|archive-date=2016-12-23}}</ref>  The person's appetite may decline to the point that the person does not want to eat at all. They may not want to get out of bed, or may need complete assistance doing so.  Commonly, the person no longer recognizes familiar people. They may have significant changes in sleeping habits or have trouble sleeping at all.<ref name="Memory Loss" />
+Changes in eating frequently occur. Caregivers of people with late-stage dementia often provide [[Purée|pureed diets]], thickened liquids, and assistance in eating, to prolong their lives, to cause them to gain weight, to reduce the risk of choking, and to make feeding the person easier.<ref>{{Cite book|url=https://books.google.com/books?id=vc_FmgEACAAJ|title=How We Die Now: Intimacy and the Work of Dying|last=Erickson|first=Karla | name-list-format = vanc |date=2013-09-27|publisher=Temple University Press|isbn=978-1439908235|pages=109–11|language=en|deadurl=no|archive-url=https://web.archive.org/web/20161223191201/https://books.google.com/books?id=vc_FmgEACAAJ|archive-date=2016-12-23}}</ref>  The person's appetite may decline to the point that the person does not want to eat at all. They may not want to get out of bed, or may need complete assistance doing so.  Commonly, the person no longer recognizes familiar people. They may have significant changes in sleeping habits or have trouble sleeping at all.<ref name="Memory Loss" />
 == Causes ==
@@ Line 113: / Line 113: @@
 === Frontotemporal dementia ===
-[[Frontotemporal Dementia|Frontotemporal dementia]]s (FTDs) are characterized by drastic personality changes and language difficulties. In all FTDs, the person has a relatively early social withdrawal and early lack of insight into the disorder. Memory problems are not a main feature of this disorder.<ref name="Memory Loss" />
+[[Frontotemporal Dementia|Frontotemporal dementias]] (FTDs) are characterized by drastic personality changes and language difficulties. In all FTDs, the person has a relatively early social withdrawal and early lack of insight into the disorder. Memory problems are not a main feature of this disorder.<ref name="Memory Loss" />
 There are three main types of FTD.  The first has major symptoms in the area of personality and behavior. This is called behavioral variant FTD (bv-FTD) and is the most common. In bv-FTD, the person shows a change in personal hygiene, becomes rigid in their thinking, and rarely recognize that there is a problem, they are socially withdrawn, and often have a drastic increase in appetite. They may also be socially inappropriate. For example, they may make inappropriate sexual comments, or may begin using pornography openly when they had not before. One of the most common signs is apathy, or not caring about anything. Apathy, however, is a common symptom in many different dementias.<ref name="Memory Loss" />
@@ Line 192: / Line 192: @@
 Normally, symptoms must be present for at least six months to support a diagnosis.<ref name=Def>{{cite web |title=Dementia definition |url=http://www.mdguidelines.com/dementia/definition |work=MDGuidelines |publisher=Reed Group |access-date=2009-06-04 |deadurl=no |archive-url=https://web.archive.org/web/20090629080241/http://www.mdguidelines.com/dementia/definition |archive-date=2009-06-29 |df= }}</ref> Cognitive dysfunction of shorter duration is called ''[[delirium]]''. Delirium can be easily confused with dementia due to similar symptoms. Delirium is characterized by a sudden onset, fluctuating course, a short duration (often lasting from hours to weeks), and is primarily related to a somatic (or medical) disturbance. In comparison, dementia has typically a long, slow onset (except in the cases of a stroke or trauma), slow decline of mental functioning, as well as a longer duration (from months to years).<ref>{{cite journal | vauthors = Caplan JP, Rabinowitz T | title = An approach to the patient with cognitive impairment: delirium and dementia | journal = The Medical Clinics of North America | volume = 94 | issue = 6 | pages = 1103–16, ix | date = November 2010 | pmid = 20951272 | doi = 10.1016/j.mcna.2010.08.004 }}</ref>
-Some [[Mental disorder|mental illness]]es, including [[depression (mood)|depression]] and [[psychosis]], may produce symptoms that must be differentiated from both delirium and dementia.<ref name=Glea>{{cite journal | vauthors = Gleason OC | title = Delirium | journal = American Family Physician | volume = 67 | issue = 5 | pages = 1027–34 | date = March 2003 | pmid = 12643363 | url = http://www.aafp.org/afp/20030301/1027.html | archive-url = https://web.archive.org/web/20070929110228/http://www.aafp.org/afp/20030301/1027.html | deadurl = no | archive-date = 2007-09-29 }}</ref> Therefore, any dementia evaluation should include a depression screening such as the Neuropsychiatric Inventory or the [[Geriatric Depression Scale]].<ref name="Memory Loss" /> Physicians used to think that anyone who came in with memory complaints had depression and not dementia (because they thought that those with dementia are generally unaware of their memory problems). This is called pseudodementia.  However, in recent years researchers have realized that many older people with memory complaints in fact have MCI, the earliest stage of dementia. Depression should always remain high on the list of possibilities, however, for an elderly person with memory trouble.
+Some [[Mental disorder|mental illnesses]], including [[depression (mood)|depression]] and [[psychosis]], may produce symptoms that must be differentiated from both delirium and dementia.<ref name=Glea>{{cite journal | vauthors = Gleason OC | title = Delirium | journal = American Family Physician | volume = 67 | issue = 5 | pages = 1027–34 | date = March 2003 | pmid = 12643363 | url = http://www.aafp.org/afp/20030301/1027.html | archive-url = https://web.archive.org/web/20070929110228/http://www.aafp.org/afp/20030301/1027.html | deadurl = no | archive-date = 2007-09-29 }}</ref> Therefore, any dementia evaluation should include a depression screening such as the Neuropsychiatric Inventory or the [[Geriatric Depression Scale]].<ref name="Memory Loss" /> Physicians used to think that anyone who came in with memory complaints had depression and not dementia (because they thought that those with dementia are generally unaware of their memory problems). This is called pseudodementia.  However, in recent years researchers have realized that many older people with memory complaints in fact have MCI, the earliest stage of dementia. Depression should always remain high on the list of possibilities, however, for an elderly person with memory trouble.
-Changes in thinking, hearing and vision are associated with normal ageing and can cause problems when diagnosing dementia due to the similarities.<ref name="Worrall, L. 2003 pp. 297-298">{{cite book | vauthors = Worrall L, Hickson LM | year = 2003 | chapter = Implications for theory, practice, and policy | pages = 297–298 | veditors = Worrall LE, Hickson LM | title = Communication disability in aging: from prevention to intervention | location = Clifton Park, NY | publisher = Delmar Learning | isbn = 978-0-7693-0015-3 }}</ref>
+Changes in thinking, hearing and vision are associated with normal ageing and can cause problems when diagnosing dementia due to the similarities.<ref name="Worrall, L. 2003 pp. 297-298">{{cite book | vauthors = Worrall L, Hickson LM | year = 2003 | chapter = Implications for theory, practice, and policy | pages = 297–98 | veditors = Worrall LE, Hickson LM | title = Communication disability in aging: from prevention to intervention | location = Clifton Park, NY | publisher = Delmar Learning | isbn = 978-0769300153 }}</ref>
 === Cognitive testing ===
@@ Line 213: / Line 213: @@
 | 83%–93.5%
 | 85%–90%
-|<ref name=pmid17178826>{{cite journal | vauthors = Cullen B, O'Neill B, Evans JJ, Coen RF, Lawlor BA | title = A review of screening tests for cognitive impairment | journal = Journal of Neurology, Neurosurgery, and Psychiatry | volume = 78 | issue = 8 | pages = 790–9 | date = August 2007 | pmid = 17178826 | pmc = 2117747 | doi = 10.1136/jnnp.2006.095414 }}</ref>
+|<ref name=pmid17178826>{{cite journal | vauthors = Cullen B, O'Neill B, Evans JJ, Coen RF, Lawlor BA | title = A review of screening tests for cognitive impairment | journal = Journal of Neurology, Neurosurgery, and Psychiatry | volume = 78 | issue = 8 | pages = 790–99 | date = August 2007 | pmid = 17178826 | pmc = 2117747 | doi = 10.1136/jnnp.2006.095414 }}</ref>
 |-
 | ''AMTS''
@@ Line 222: / Line 222: @@
 There are some brief tests (5–15 minutes) that have reasonable reliability to screen for dementia.
-While many tests have been studied,<ref name=pmid17163083>{{cite journal | vauthors = Sager MA, Hermann BP, La Rue A, Woodard JL | title = Screening for dementia in community-based memory clinics | journal = WMJ | volume = 105 | issue = 7 | pages = 25–9 | date = October 2006 | pmid = 17163083 | url = http://www.wisconsinmedicalsociety.org/_WMS/publications/wmj/issues/wmj_v105n7/sager.pdf | format = PDF | archive-url = https://web.archive.org/web/20100626094646/http://www.wisconsinmedicalsociety.org/_WMS/publications/wmj/issues/wmj_v105n7/sager.pdf | df =  | deadurl = yes | archive-date = 2010-06-26 }}</ref><ref name=pmid17287448>{{cite journal | vauthors = Fleisher AS, Sowell BB, Taylor C, Gamst AC, Petersen RC, Thal LJ | title = Clinical predictors of progression to Alzheimer disease in amnestic mild cognitive impairment | journal = Neurology | volume = 68 | issue = 19 | pages = 1588–95 | date = May 2007 | pmid = 17287448 | doi = 10.1212/01.wnl.0000258542.58725.4c }}</ref><ref name=pmid12614094>{{cite journal | vauthors = Karlawish JH, Clark CM | title = Diagnostic evaluation of elderly patients with mild memory problems | journal = Annals of Internal Medicine | volume = 138 | issue = 5 | pages = 411–9 | date = March 2003 | pmid = 12614094 | doi = 10.7326/0003-4819-138-5-200303040-00011 | url = http://www.annals.org/cgi/content/full/138/5/411 | archive-url = https://web.archive.org/web/20070518222849/http://www.annals.org/cgi/content/full/138/5/411 | df =  | deadurl = no | archive-date = 2007-05-18 }}</ref>  presently the [[mini mental state examination]] (MMSE) is the best studied and most commonly used. The MMSE is a useful tool for helping to diagnose dementia if the results are interpreted along with an assessment of a person's personality, their ability to perform activities of daily living, and their behaviour.<ref>{{cite journal | vauthors = Creavin ST, Wisniewski S, Noel-Storr AH, Trevelyan CM, Hampton T, Rayment D, Thom VM, Nash KJ, Elhamoui H, Milligan R, Patel AS, Tsivos DV, Wing T, Phillips E, Kellman SM, Shackleton HL, Singleton GF, Neale BE, Watton ME, Cullum S | display-authors = 6 | title = Mini-Mental State Examination (MMSE) for the detection of dementia in clinically unevaluated people aged 65 and over in community and primary care populations | journal = The Cochrane Database of Systematic Reviews | issue = 1 | pages = CD011145 | date = January 2016 | pmid = 26760674 | doi = 10.1002/14651858.CD011145.pub2 }}</ref> Other cognitive tests include the [[abbreviated mental test score]] (AMTS), the, ''Modified Mini-Mental State Examination'' (3MS),<ref name=pmid3611032>{{cite journal | vauthors = Teng EL, Chui HC | title = The Modified Mini-Mental State (3MS) examination | journal = The Journal of Clinical Psychiatry | volume = 48 | issue = 8 | pages = 314–8 | date = August 1987 | pmid = 3611032 }}</ref> the ''Cognitive Abilities Screening Instrument'' (CASI),<ref name= pmid8054493>{{cite journal | vauthors = Teng EL, Hasegawa K, Homma A, Imai Y, Larson E, Graves A, Sugimoto K, Yamaguchi T, Sasaki H, Chiu D | display-authors = 6 | title = The Cognitive Abilities Screening Instrument (CASI): a practical test for cross-cultural epidemiological studies of dementia | journal = International Psychogeriatrics | volume = 6 | issue = 1 | pages = 45–58; discussion 62 | year = 1994 | pmid = 8054493 | doi = 10.1017/S1041610294001602 }}</ref> the [[Trail-making test]],<ref>{{cite journal | vauthors = Tombaugh TN | title = Trail Making Test A and B: normative data stratified by age and education | journal = Archives of Clinical Neuropsychology | volume = 19 | issue = 2 | pages = 203–14 | date = March 2004 | pmid = 15010086 | doi = 10.1016/S0887-6177(03)00039-8 }}</ref> and the clock drawing test.<ref name=pmid9598672>{{cite journal | vauthors = Royall DR, Cordes JA, Polk M | title = CLOX: an executive clock drawing task | journal = Journal of Neurology, Neurosurgery, and Psychiatry | volume = 64 | issue = 5 | pages = 588–94 | date = May 1998 | pmid = 9598672 | pmc = 2170069 | doi = 10.1136/jnnp.64.5.588 }}</ref> The MOCA ([[Montreal Cognitive Assessment]]) is a very reliable screening test and is available online for free in 35 different languages.<ref name="Memory Loss" /> The MOCA has also been shown somewhat better at detecting mild cognitive impairment than the MMSE.<ref>{{cite journal|vauthors=Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H|date=April 2005|title=The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment|journal=Journal of the American Geriatrics Society|volume=53|issue=4|pages=695–9|doi=10.1111/j.1532-5415.2005.53221.x|pmid=15817019}}<!--|access-date=24 April 2014 --></ref> Brief cognitive tests may be affected by factors such as age, education and ethnicity.<ref>{{Cite journal|last=Ranson|first=Janice M.|last2=Kuźma|first2=Elżbieta|last3=Hamilton|first3=William|last4=Muniz-Terrera|first4=Graciela|last5=Langa|first5=Kenneth M.|last6=Llewellyn|first6=David J.|date=2018-11-28|title=Predictors of dementia misclassification when using brief cognitive assessments|url=http://cp.neurology.org/content/early/2018/11/28/CPJ.0000000000000566|journal=Neurology: Clinical Practice|language=en|pages=10.1212/CPJ.0000000000000566|doi=10.1212/CPJ.0000000000000566|issn=2163-0402}}</ref>
+While many tests have been studied,<ref name=pmid17163083>{{cite journal | vauthors = Sager MA, Hermann BP, La Rue A, Woodard JL | title = Screening for dementia in community-based memory clinics | journal = WMJ | volume = 105 | issue = 7 | pages = 25–29 | date = October 2006 | pmid = 17163083 | url = http://www.wisconsinmedicalsociety.org/_WMS/publications/wmj/issues/wmj_v105n7/sager.pdf | format = PDF | archive-url = https://web.archive.org/web/20100626094646/http://www.wisconsinmedicalsociety.org/_WMS/publications/wmj/issues/wmj_v105n7/sager.pdf | df =  | deadurl = yes | archive-date = 2010-06-26 }}</ref><ref name=pmid17287448>{{cite journal | vauthors = Fleisher AS, Sowell BB, Taylor C, Gamst AC, Petersen RC, Thal LJ | title = Clinical predictors of progression to Alzheimer disease in amnestic mild cognitive impairment | journal = Neurology | volume = 68 | issue = 19 | pages = 1588–95 | date = May 2007 | pmid = 17287448 | doi = 10.1212/01.wnl.0000258542.58725.4c }}</ref><ref name=pmid12614094>{{cite journal | vauthors = Karlawish JH, Clark CM | title = Diagnostic evaluation of elderly patients with mild memory problems | journal = Annals of Internal Medicine | volume = 138 | issue = 5 | pages = 411–19 | date = March 2003 | pmid = 12614094 | doi = 10.7326/0003-4819-138-5-200303040-00011 | url = http://www.annals.org/cgi/content/full/138/5/411 | archive-url = https://web.archive.org/web/20070518222849/http://www.annals.org/cgi/content/full/138/5/411 | df =  | deadurl = no | archive-date = 2007-05-18 }}</ref>  presently the [[mini mental state examination]] (MMSE) is the best studied and most commonly used. The MMSE is a useful tool for helping to diagnose dementia if the results are interpreted along with an assessment of a person's personality, their ability to perform activities of daily living, and their behaviour.<ref>{{cite journal | vauthors = Creavin ST, Wisniewski S, Noel-Storr AH, Trevelyan CM, Hampton T, Rayment D, Thom VM, Nash KJ, Elhamoui H, Milligan R, Patel AS, Tsivos DV, Wing T, Phillips E, Kellman SM, Shackleton HL, Singleton GF, Neale BE, Watton ME, Cullum S | display-authors = 6 | title = Mini-Mental State Examination (MMSE) for the detection of dementia in clinically unevaluated people aged 65 and over in community and primary care populations | journal = The Cochrane Database of Systematic Reviews | issue = 1 | pages = CD011145 | date = January 2016 | pmid = 26760674 | doi = 10.1002/14651858.CD011145.pub2 }}</ref> Other cognitive tests include the [[abbreviated mental test score]] (AMTS), the, ''Modified Mini-Mental State Examination'' (3MS),<ref name=pmid3611032>{{cite journal | vauthors = Teng EL, Chui HC | title = The Modified Mini-Mental State (3MS) examination | journal = The Journal of Clinical Psychiatry | volume = 48 | issue = 8 | pages = 314–8 | date = August 1987 | pmid = 3611032 }}</ref> the ''Cognitive Abilities Screening Instrument'' (CASI),<ref name= pmid8054493>{{cite journal | vauthors = Teng EL, Hasegawa K, Homma A, Imai Y, Larson E, Graves A, Sugimoto K, Yamaguchi T, Sasaki H, Chiu D | display-authors = 6 | title = The Cognitive Abilities Screening Instrument (CASI): a practical test for cross-cultural epidemiological studies of dementia | journal = International Psychogeriatrics | volume = 6 | issue = 1 | pages = 45–58; discussion 62 | year = 1994 | pmid = 8054493 | doi = 10.1017/S1041610294001602 }}</ref> the [[Trail-making test]],<ref>{{cite journal | vauthors = Tombaugh TN | title = Trail Making Test A and B: normative data stratified by age and education | journal = Archives of Clinical Neuropsychology | volume = 19 | issue = 2 | pages = 203–14 | date = March 2004 | pmid = 15010086 | doi = 10.1016/S0887-6177(03)00039-8 }}</ref> and the clock drawing test.<ref name=pmid9598672>{{cite journal | vauthors = Royall DR, Cordes JA, Polk M | title = CLOX: an executive clock drawing task | journal = Journal of Neurology, Neurosurgery, and Psychiatry | volume = 64 | issue = 5 | pages = 588–94 | date = May 1998 | pmid = 9598672 | pmc = 2170069 | doi = 10.1136/jnnp.64.5.588 }}</ref> The MOCA ([[Montreal Cognitive Assessment]]) is a very reliable screening test and is available online for free in 35 different languages.<ref name="Memory Loss" /> The MOCA has also been shown somewhat better at detecting mild cognitive impairment than the MMSE.<ref>{{cite journal|vauthors=Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H|date=April 2005|title=The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment|journal=Journal of the American Geriatrics Society|volume=53|issue=4|pages=695–99|doi=10.1111/j.1532-5415.2005.53221.x|pmid=15817019}}<!--|access-date=24 April 2014 --></ref> Brief cognitive tests may be affected by factors such as age, education and ethnicity.<ref>{{Cite journal|last=Ranson|first=Janice M.|last2=Kuźma|first2=Elżbieta|last3=Hamilton|first3=William|last4=Muniz-Terrera|first4=Graciela|last5=Langa|first5=Kenneth M.|last6=Llewellyn|first6=David J.|date=2018-11-28|title=Predictors of dementia misclassification when using brief cognitive assessments|url=http://cp.neurology.org/content/early/2018/11/28/CPJ.0000000000000566|journal=Neurology: Clinical Practice|language=en|pages=10.1212/CPJ.0000000000000566|doi=10.1212/CPJ.0000000000000566|issn=2163-0402}}</ref>
 Another approach to screening for dementia is to ask an informant (relative or other supporter) to fill out a questionnaire about the person's everyday cognitive functioning. Informant questionnaires provide complementary information to brief cognitive tests. Probably the best known questionnaire of this sort is the ''[[Informant Questionnaire on Cognitive Decline in the Elderly]] (IQCODE)''.<ref>{{cite journal | vauthors = Jorm AF | title = The Informant Questionnaire on cognitive decline in the elderly (IQCODE): a review | journal = International Psychogeriatrics | volume = 16 | issue = 3 | pages = 275–93 | date = September 2004 | pmid = 15559753 | doi = 10.1017/S1041610204000390 }}</ref> There is not sufficient evidence to determine how accurate the IQCODE is for diagnosing or predicting dementia.<ref>{{cite journal | vauthors = Harrison JK, Stott DJ, McShane R, Noel-Storr AH, Swann-Price RS, Quinn TJ | title = Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for the early diagnosis of dementia across a variety of healthcare settings | journal = The Cochrane Database of Systematic Reviews | volume = 11 | pages = CD011333 | date = November 2016 | pmid = 27869298 | doi = 10.1002/14651858.cd011333.pub2 | url = http://www.cochrane.org/CD011333/DEMENTIA_using-structured-questionnaire-iqcode-detect-individuals-who-may-go-develop-dementia | archive-url = https://web.archive.org/web/20161126132113/http://www.cochrane.org/CD011333/DEMENTIA_using-structured-questionnaire-iqcode-detect-individuals-who-may-go-develop-dementia | df =  | deadurl = no | archive-date = 2016-11-26 }}url=http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011333.pub2/abstract|{{Dead link|date=December 2018 |bot=InternetArchiveBot |fix-attempted=yes }}</ref> The Alzheimer's Disease Caregiver Questionnaire is another tool. It is about 90% accurate for Alzheimer's and can be completed online or in the office by a caregiver.<ref name="Memory Loss" />  On the other hand, the ''[[General Practitioner Assessment Of Cognition]]'' combines both, a patient assessment and an informant interview. It was specifically designed for the use in the primary care setting.
@@ Line 234: / Line 234: @@
 A [[computed axial tomography|CT scan]] or [[magnetic resonance imaging]] (MRI scan) is commonly performed, although these tests do not pick up diffuse metabolic changes associated with dementia in a person that shows no gross neurological problems (such as paralysis or weakness) on neurological exam.{{Citation needed|date=July 2017}} CT or MRI may suggest [[normal pressure hydrocephalus]], a potentially reversible cause of dementia, and can yield information relevant to other types of dementia, such as infarction ([[stroke]]) that would point at a vascular type of dementia.
-The [[functional neuroimaging]] modalities of [[SPECT]] and [[Positron emission tomography|PET]] are more useful in assessing long-standing cognitive dysfunction, since they have shown similar ability to diagnose dementia as a clinical exam and cognitive testing.<ref>{{cite journal | vauthors = Bonte FJ, Harris TS, Hynan LS, Bigio EH, White CL | title = Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation | journal = Clinical Nuclear Medicine | volume = 31 | issue = 7 | pages = 376–8 | date = July 2006 | pmid = 16785801 | doi = 10.1097/01.rlu.0000222736.81365.63 }}</ref> The ability of SPECT to differentiate the vascular cause (i.e., [[multi-infarct dementia]]) from Alzheimer's disease dementias, appears superior to differentiation by clinical exam.<ref>{{cite journal | vauthors = Dougall NJ, Bruggink S, Ebmeier KP | title = Systematic review of the diagnostic accuracy of 99mTc-HMPAO-SPECT in dementia | journal = The American Journal of Geriatric Psychiatry | volume = 12 | issue = 6 | pages = 554–70 | year = 2004 | pmid = 15545324 | doi = 10.1176/appi.ajgp.12.6.554 }}</ref>
+The [[functional neuroimaging]] modalities of [[SPECT]] and [[Positron emission tomography|PET]] are more useful in assessing long-standing cognitive dysfunction, since they have shown similar ability to diagnose dementia as a clinical exam and cognitive testing.<ref>{{cite journal | vauthors = Bonte FJ, Harris TS, Hynan LS, Bigio EH, White CL | title = Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation | journal = Clinical Nuclear Medicine | volume = 31 | issue = 7 | pages = 376–78 | date = July 2006 | pmid = 16785801 | doi = 10.1097/01.rlu.0000222736.81365.63 }}</ref> The ability of SPECT to differentiate the vascular cause (i.e., [[multi-infarct dementia]]) from Alzheimer's disease dementias, appears superior to differentiation by clinical exam.<ref>{{cite journal | vauthors = Dougall NJ, Bruggink S, Ebmeier KP | title = Systematic review of the diagnostic accuracy of 99mTc-HMPAO-SPECT in dementia | journal = The American Journal of Geriatric Psychiatry | volume = 12 | issue = 6 | pages = 554–70 | year = 2004 | pmid = 15545324 | doi = 10.1176/appi.ajgp.12.6.554 }}</ref>
 Recent research has established the value of PET imaging using carbon-11 Pittsburgh Compound B as a radiotracer (PIB-PET) in predictive diagnosis of various kinds of dementia, in particular [[Alzheimer's disease]]. Studies from Australia have found PIB-PET 86% accurate in predicting which patients with mild cognitive impairment will develop Alzheimer's disease within two years. In another study, carried out using 66 patients seen at the University of Michigan, PET studies using either PIB or another radiotracer, carbon-11 dihydrotetrabenazine (DTBZ), led to more accurate diagnosis for more than one-fourth of patients with mild cognitive impairment or mild dementia.<ref>{{cite journal | vauthors = Abella HA |title=Report from SNM: PET imaging of brain chemistry bolsters characterization of dementias |journal=Diagnostic Imaging |date=June 16, 2009 |url=http://www.diagnosticimaging.com/imaging-trends-advances/cardiovascular-imaging/article/113619/1423022 }}{{dead link|date=March 2018 |bot=InternetArchiveBot |fix-attempted=yes }}</ref>
@@ Line 246: / Line 246: @@
 ==Management==
-Except for the treatable types listed above, there is no cure. [[Acetylcholinesterase inhibitor|Cholinesterase inhibitor]]s are often used early in the disorder course; however, benefit is generally small.<ref name="Comm2012"/><ref>{{cite journal | vauthors = Schneider LS, Mangialasche F, Andreasen N, Feldman H, Giacobini E, Jones R, Mantua V, Mecocci P, Pani L, Winblad B, Kivipelto M | title = Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014 | journal = Journal of Internal Medicine | volume = 275 | issue = 3 | pages = 251–83 | date = March 2014 | pmid = 24605808 | pmc = 3956752 | doi = 10.1111/joim.12191 }}</ref> Cognitive and behavioral interventions may be appropriate.  There is some evidence that educating and providing support for the person with dementia, as well as caregivers and family members, improves outcomes.<ref>{{cite journal | vauthors = Vandepitte S, Van Den Noortgate N, Putman K, Verhaeghe S, Verdonck C, Annemans L | title = Effectiveness of respite care in supporting informal caregivers of persons with dementia: a systematic review | journal = International Journal of Geriatric Psychiatry | volume = 31 | issue = 12 | pages = 1277–1288 | date = December 2016 | pmid = 27245986 | doi = 10.1002/gps.4504 }}</ref> Exercise programs are beneficial with respect to activities of daily living and potentially improve dementia.<ref name=Forb2015/>
+Except for the treatable types listed above, there is no cure. [[Acetylcholinesterase inhibitor|Cholinesterase inhibitors]] are often used early in the disorder course; however, benefit is generally small.<ref name="Comm2012"/><ref>{{cite journal | vauthors = Schneider LS, Mangialasche F, Andreasen N, Feldman H, Giacobini E, Jones R, Mantua V, Mecocci P, Pani L, Winblad B, Kivipelto M | title = Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014 | journal = Journal of Internal Medicine | volume = 275 | issue = 3 | pages = 251–83 | date = March 2014 | pmid = 24605808 | pmc = 3956752 | doi = 10.1111/joim.12191 }}</ref> Cognitive and behavioral interventions may be appropriate.  There is some evidence that educating and providing support for the person with dementia, as well as caregivers and family members, improves outcomes.<ref>{{cite journal | vauthors = Vandepitte S, Van Den Noortgate N, Putman K, Verhaeghe S, Verdonck C, Annemans L | title = Effectiveness of respite care in supporting informal caregivers of persons with dementia: a systematic review | journal = International Journal of Geriatric Psychiatry | volume = 31 | issue = 12 | pages = 1277–88 | date = December 2016 | pmid = 27245986 | doi = 10.1002/gps.4504 }}</ref> Exercise programs are beneficial with respect to activities of daily living and potentially improve dementia.<ref name=Forb2015/>
 ===Psychological therapies===
@@ Line 252: / Line 252: @@
 [[Psychological therapies]] for dementia include some limited evidence for [[reminiscence therapy]] (namely, some positive effects in the areas of quality of life, cognition, communication and mood - the first three particularly in care home settings),<ref>{{cite journal |last1=Woods |first1=B |last2=O'Philbin |first2=L |last3=Farrell |first3=EM |last4=Spector |first4=AE |last5=Orrell |first5=M |title=Reminiscence therapy for dementia |journal=Cochrane Database Syst Rev. |date=2018 |volume=3 |page=CD001120 |doi=10.1002/14651858.CD001120.pub3 |pmid=29493789 |url=http://discovery.ucl.ac.uk/1345239/ }}</ref> some benefit for [[cognitive reframing]] for caretakers,<ref>{{cite journal | vauthors = Vernooij-Dassen M, Draskovic I, McCleery J, Downs M | title = Cognitive reframing for carers of people with dementia | journal = The Cochrane Database of Systematic Reviews | issue = 11 | pages = CD005318 | date = November 2011 | pmid = 22071821 | doi = 10.1002/14651858.CD005318.pub2 | hdl = 2066/97731 }}</ref> unclear evidence for [[validation therapy]],<ref>{{cite journal | vauthors = Neal M, Barton Wright P | title = Validation therapy for dementia | journal = The Cochrane Database of Systematic Reviews | issue = 3 | pages = CD001394 | year = 2003 | pmid = 12917907 | doi = 10.1002/14651858.CD001394 }}</ref> and tentative evidence for [[mental exercise]]s, such as cognitive stimulation programs for people with mild to moderate dementia.<ref>{{cite journal | vauthors = Woods B, Aguirre E, Spector AE, Orrell M | title = Cognitive stimulation to improve cognitive functioning in people with dementia | journal = The Cochrane Database of Systematic Reviews | volume = 2 | issue = 2 | pages = CD005562 | date = February 2012 | pmid = 22336813 | doi = 10.1002/14651858.CD005562.pub2 }}</ref> Reminiscence therapy can improve quality of life, cognition, communication, and possibly mood in people with dementia in some circumstances, although all of these benefits may be small.<ref>{{Cite journal|last=Woods|first=Bob|last2=O'Philbin|first2=Laura|last3=Farrell|first3=Emma M.|last4=Spector|first4=Aimee E.|last5=Orrell|first5=Martin|date=March 1, 2018|title=Reminiscence therapy for dementia|journal=The Cochrane Database of Systematic Reviews|volume=3|pages=CD001120|doi=10.1002/14651858.CD001120.pub3|issn=1469-493X|pmid=29493789|url=http://discovery.ucl.ac.uk/1345239/}}</ref>
-[[Adult daycare]] centers as well as special care units in nursing homes often provide specialized care for dementia patients. Adult daycare centers offer supervision, recreation, meals, and limited health care to participants, as well as providing respite for caregivers. In addition, [[home care]] can provide one-on-one support and care in the home allowing for more individualized attention that is needed as the disorder progresses. Psychiatric nurses can make a distinctive contribution to people's mental health.<ref>{{cite book | last = Barker | first = Philip | name-list-format = vanc | title = Psychiatric and mental health nursing: the craft of caring |publisher=Arnold |location=London |year=2003 |isbn=978-0-340-81026-2 |oclc=53373798}}</ref>
+[[Adult daycare]] centers as well as special care units in nursing homes often provide specialized care for dementia patients. Adult daycare centers offer supervision, recreation, meals, and limited health care to participants, as well as providing respite for caregivers. In addition, [[home care]] can provide one-on-one support and care in the home allowing for more individualized attention that is needed as the disorder progresses. Psychiatric nurses can make a distinctive contribution to people's mental health.<ref>{{cite book | last = Barker | first = Philip | name-list-format = vanc | title = Psychiatric and mental health nursing: the craft of caring |publisher=Arnold |location=London |year=2003 |isbn=978-0340810262 |oclc=53373798}}</ref>
-Since dementia impairs normal communication due to changes in receptive and expressive language, as well as the ability to plan and problem solve, agitated behaviour is often a form of communication for the person with dementia. Actively searching for a potential cause, such as pain, physical illness, or overstimulation can be helpful in reducing agitation.<ref name="Weitzel 2011">{{cite journal | vauthors = Weitzel T, Robinson S, Barnes MR, Berry TA, Holmes JM, Mercer S, Foster T, Allen L, Victor DA, Vollmer CM, Steinkruger K, Friedrich LA, Plunkett D, Kirkbride GL | display-authors = 6 | title = The special needs of the hospitalized patient with dementia | journal = Medsurg Nursing | volume = 20 | issue = 1 | pages = 13–8; quiz 19 | year = 2011 | pmid = 21446290 | doi = }}</ref> Additionally, using an "ABC analysis of behaviour" can be a useful tool for understanding behavior in people with dementia. It involves looking at the antecedents (A), behavior (B), and consequences (C) associated with an event to help define the problem and prevent further incidents that may arise if the person's needs are misunderstood.<ref>{{cite journal | vauthors = Cunningham C | title = Understanding challenging behaviour in patients with dementia | journal = Nursing Standard | volume = 20 | issue = 47 | pages = 42–5 | year = 2006 | pmid = 16913375 | doi = 10.7748/ns2006.08.20.47.42.c4477 }}</ref> The strongest evidence for non-pharmacological therapies for the management of changed behaviours in dementia is for using such approaches.<ref name=Dyer2017>{{cite journal |last1=Dyer |first1=Suzanne M. |last2=Harrison |first2=Stephanie L. |last3=Laver |first3=Kate |last4=Whitehead |first4=Craig |last5=Crotty |first5=Maria |title=An overview of systematic reviews of pharmacological and non-pharmacological interventions for the treatment of behavioral and psychological symptoms of dementia |journal=International Psychogeriatrics |date=16 November 2017 |volume=30 |issue=03 |pages=295–309 |doi=10.1017/S1041610217002344}}</ref> There is low quality evidence that regular (at least five sessions of) [[music therapy]] may be help resident in institutions. It may reduce depressive symptoms and improves overall behavioural problems. There may also be a beneficial effect on emotional well-being and quality of life, as well as reducing anxiety.<ref>{{cite journal |last1=van der Steen |first1=JT |last2=Smaling |first2=HJ |last3=van der Wouden |first3=JC |last4=Bruinsma |first4=MS |last5=Scholten |first5=RJ |last6=Vink |first6=AC |title=Music-based therapeutic interventions for people with dementia |journal=Cochrane Database Syst Rev. |date=2018 |volume=7 |page=CD003477 |doi=10.1002/14651858.CD003477.pub4 |pmid=30033623 |hdl=1874/350441 }}</ref>
+Since dementia impairs normal communication due to changes in receptive and expressive language, as well as the ability to plan and problem solve, agitated behaviour is often a form of communication for the person with dementia. Actively searching for a potential cause, such as pain, physical illness, or overstimulation can be helpful in reducing agitation.<ref name="Weitzel 2011">{{cite journal | vauthors = Weitzel T, Robinson S, Barnes MR, Berry TA, Holmes JM, Mercer S, Foster T, Allen L, Victor DA, Vollmer CM, Steinkruger K, Friedrich LA, Plunkett D, Kirkbride GL | display-authors = 6 | title = The special needs of the hospitalized patient with dementia | journal = Medsurg Nursing | volume = 20 | issue = 1 | pages = 13–18; quiz 19 | year = 2011 | pmid = 21446290 | doi = }}</ref> Additionally, using an "ABC analysis of behaviour" can be a useful tool for understanding behavior in people with dementia. It involves looking at the antecedents (A), behavior (B), and consequences (C) associated with an event to help define the problem and prevent further incidents that may arise if the person's needs are misunderstood.<ref>{{cite journal | vauthors = Cunningham C | title = Understanding challenging behaviour in patients with dementia | journal = Nursing Standard | volume = 20 | issue = 47 | pages = 42–45 | year = 2006 | pmid = 16913375 | doi = 10.7748/ns2006.08.20.47.42.c4477 }}</ref> The strongest evidence for non-pharmacological therapies for the management of changed behaviours in dementia is for using such approaches.<ref name=Dyer2017>{{cite journal |last1=Dyer |first1=Suzanne M. |last2=Harrison |first2=Stephanie L. |last3=Laver |first3=Kate |last4=Whitehead |first4=Craig |last5=Crotty |first5=Maria |title=An overview of systematic reviews of pharmacological and non-pharmacological interventions for the treatment of behavioral and psychological symptoms of dementia |journal=International Psychogeriatrics |date=16 November 2017 |volume=30 |issue=03 |pages=295–309 |doi=10.1017/S1041610217002344}}</ref> There is low quality evidence that regular (at least five sessions of) [[music therapy]] may be help resident in institutions. It may reduce depressive symptoms and improves overall behavioural problems. There may also be a beneficial effect on emotional well-being and quality of life, as well as reducing anxiety.<ref>{{cite journal |last1=van der Steen |first1=JT |last2=Smaling |first2=HJ |last3=van der Wouden |first3=JC |last4=Bruinsma |first4=MS |last5=Scholten |first5=RJ |last6=Vink |first6=AC |title=Music-based therapeutic interventions for people with dementia |journal=Cochrane Database Syst Rev. |date=2018 |volume=7 |page=CD003477 |doi=10.1002/14651858.CD003477.pub4 |pmid=30033623 |hdl=1874/350441 }}</ref>
 ===Medications===
@@ Line 273: / Line 273: @@
 ===Pain===
-<!--This section is linked from [[Pain#In_nonverbal_patients]]-->
+<!--This section is linked from [[Pain#In nonverbal patients]]-->
 {{See also|Pain#In nonverbal patients|l1=Assessment in nonverbal patients}}
-As people age, they experience more health problems, and most health problems associated with aging carry a substantial burden of pain; therefore, between 25% and 50% of older adults experience persistent pain. Seniors with dementia experience the same prevalence of conditions likely to cause pain as seniors without dementia.<ref name="Hadjistavropoulos 2007">{{cite journal | vauthors = Hadjistavropoulos T, Herr K, Turk DC, Fine PG, Dworkin RH, Helme R, Jackson K, Parmelee PA, Rudy TE, Lynn Beattie B, Chibnall JT, Craig KD, Ferrell B, Ferrell B, Fillingim RB, Gagliese L, Gallagher R, Gibson SJ, Harrison EL, Katz B, Keefe FJ, Lieber SJ, Lussier D, Schmader KE, Tait RC, Weiner DK, Williams J | title = An interdisciplinary expert consensus statement on assessment of pain in older persons | journal = The Clinical Journal of Pain | volume = 23 | issue = 1 Suppl | pages = S1–43 | date = January 2007 | pmid = 17179836 | doi = 10.1097/AJP.0b013e31802be869 }}</ref> Pain is often overlooked in older adults and, when screened for, often poorly assessed, especially among those with dementia since they become incapable of informing others that they're in pain.<ref name="Hadjistavropoulos 2007"/><ref name=Shega>{{cite journal | vauthors = Shega J, Emanuel L, Vargish L, Levine SK, Bursch H, Herr K, Karp JF, Weiner DK | title = Pain in persons with dementia: complex, common, and challenging | journal = The Journal of Pain | volume = 8 | issue = 5 | pages = 373–8 | date = May 2007 | pmid = 17485039 | doi = 10.1016/j.jpain.2007.03.003 }}</ref> Beyond the issue of humane care, unrelieved pain has functional implications. Persistent pain can lead to decreased ambulation, depressed mood, sleep disturbances, impaired appetite, and exacerbation of cognitive impairment,<ref name= Shega/> and pain-related interference with activity is a factor contributing to falls in the elderly.<ref name="Hadjistavropoulos 2007"/><ref name=Blyth>{{cite journal | vauthors = Blyth FM, Cumming R, Mitchell P, Wang JJ | title = Pain and falls in older people | journal = European Journal of Pain | volume = 11 | issue = 5 | pages = 564–71 | date = July 2007 | pmid = 17015026 | doi = 10.1016/j.ejpain.2006.08.001 }}</ref>
+As people age, they experience more health problems, and most health problems associated with aging carry a substantial burden of pain; therefore, between 25% and 50% of older adults experience persistent pain. Seniors with dementia experience the same prevalence of conditions likely to cause pain as seniors without dementia.<ref name="Hadjistavropoulos 2007">{{cite journal | vauthors = Hadjistavropoulos T, Herr K, Turk DC, Fine PG, Dworkin RH, Helme R, Jackson K, Parmelee PA, Rudy TE, Lynn Beattie B, Chibnall JT, Craig KD, Ferrell B, Ferrell B, Fillingim RB, Gagliese L, Gallagher R, Gibson SJ, Harrison EL, Katz B, Keefe FJ, Lieber SJ, Lussier D, Schmader KE, Tait RC, Weiner DK, Williams J | title = An interdisciplinary expert consensus statement on assessment of pain in older persons | journal = The Clinical Journal of Pain | volume = 23 | issue = 1 Suppl | pages = S1–43 | date = January 2007 | pmid = 17179836 | doi = 10.1097/AJP.0b013e31802be869 }}</ref> Pain is often overlooked in older adults and, when screened for, often poorly assessed, especially among those with dementia since they become incapable of informing others that they're in pain.<ref name="Hadjistavropoulos 2007"/><ref name=Shega>{{cite journal | vauthors = Shega J, Emanuel L, Vargish L, Levine SK, Bursch H, Herr K, Karp JF, Weiner DK | title = Pain in persons with dementia: complex, common, and challenging | journal = The Journal of Pain | volume = 8 | issue = 5 | pages = 373–78 | date = May 2007 | pmid = 17485039 | doi = 10.1016/j.jpain.2007.03.003 }}</ref> Beyond the issue of humane care, unrelieved pain has functional implications. Persistent pain can lead to decreased ambulation, depressed mood, sleep disturbances, impaired appetite, and exacerbation of cognitive impairment,<ref name= Shega/> and pain-related interference with activity is a factor contributing to falls in the elderly.<ref name="Hadjistavropoulos 2007"/><ref name=Blyth>{{cite journal | vauthors = Blyth FM, Cumming R, Mitchell P, Wang JJ | title = Pain and falls in older people | journal = European Journal of Pain | volume = 11 | issue = 5 | pages = 564–71 | date = July 2007 | pmid = 17015026 | doi = 10.1016/j.ejpain.2006.08.001 }}</ref>
 Although persistent pain in the person with dementia is difficult to communicate, diagnose, and treat, failure to address persistent pain has profound functional, [[psychosocial]], and [[quality of life]] implications for this vulnerable population. Health professionals often lack the skills and usually lack the time needed to recognize, accurately assess, and adequately monitor pain in people with dementia.<ref name="Hadjistavropoulos 2007"/><ref name=Brown>{{cite journal |last1=Brown |first1=C. |year=2009 |title=Pain, aging and dementia: The crisis is looming, but are we ready? |journal=British Journal of Occupational Therapy |volume=72 |issue=8 |pages=371–75 |url=http://www.ingentaconnect.com/content/cot/bjot/2009/00000072/00000008/art00007 |deadurl=no |archive-url=https://web.archive.org/web/20131019165628/http://www.ingentaconnect.com/content/cot/bjot/2009/00000072/00000008/art00007 |archive-date=2013-10-19 |df= }}</ref> Family members and friends can make a valuable contribution to the care of a person with dementia by learning to recognize and assess their pain. Educational resources (such as the {{Plain link|url=http://www.painanddementia.ualberta.ca |name=Understand Pain and Dementia}} tutorial) and observational assessment tools are available.<ref name= "Hadjistavropoulos 2007"/><ref name=Herr>{{cite journal | vauthors = Herr K, Bjoro K, Decker S | title = Tools for assessment of pain in nonverbal older adults with dementia: a state-of-the-science review | journal = Journal of Pain and Symptom Management | volume = 31 | issue = 2 | pages = 170–92 | date = February 2006 | pmid = 16488350 | doi = 10.1016/j.jpainsymman.2005.07.001 }}</ref><ref name=Stolee2005>{{cite journal | vauthors = Stolee P, Hillier LM, Esbaugh J, Bol N, McKellar L, Gauthier N | title = Instruments for the assessment of pain in older persons with cognitive impairment | journal = Journal of the American Geriatrics Society | volume = 53 | issue = 2 | pages = 319–26 | date = February 2005 | pmid = 15673359 | doi = 10.1111/j.1532-5415.2005.53121.x }}</ref>
@@ Line 282: / Line 282: @@
 Persons with dementia may have difficulty eating. Whenever it is available as an option, the recommended response to eating problems is having a caretaker do [[assisted feeding]] for the person.<ref name="AGSantipsychotic"/> A secondary option for people who cannot swallow effectively is to consider [[Percutaneous endoscopic gastrostomy|gastrostomy]] [[feeding tube]] placement as a way to give nutrition. However, in bringing person comfort and keeping functional status while lowering risk of aspiration pneumonia and death, assistance with oral feeding is at least as good as tube feeding.<ref name="AGSantipsychotic"/><ref>{{Citation |author1 = AMDA – The Society for Post-Acute and Long-Term Care Medicine |author1-link = AMDA – The Society for Post-Acute and Long-Term Care Medicine |date = February 2014 |title = Five Things Physicians and Patients Should Question |publisher = AMDA – The Society for Post-Acute and Long-Term Care Medicine |work = [[Choosing Wisely]]: an initiative of the [[ABIM Foundation]] |page =  |url = http://www.choosingwisely.org/doctor-patient-lists/amda/ |access-date = 10 February 2013 |deadurl = no |archive-url = https://web.archive.org/web/20140913011101/http://www.choosingwisely.org/doctor-patient-lists/amda/ |archive-date = 13 September 2014 |df =  }}</ref> Tube-feeding is associated with agitation, increased use of physical and chemical restraints, and worsening pressure ulcers. Tube feedings may also cause fluid overload, diarrhea, abdominal pain, local complications, less human interaction, and may increase the risk of aspiration.<ref>{{Citation |author1 = AMDA – The Society for Post-Acute and Long-Term Care Medicine |author1-link = AMDA – The Society for Post-Acute and Long-Term Care Medicine |date = February 2014 |title = Five Things Physicians and Patients Should Question |publisher = AMDA – The Society for Post-Acute and Long-Term Care Medicine |work = [[Choosing Wisely]]: an initiative of the [[ABIM Foundation]] |page =  |url = http://www.choosingwisely.org/doctor-patient-lists/amda/ |access-date = 10 February 2013 |deadurl = no |archive-url = https://web.archive.org/web/20140913011101/http://www.choosingwisely.org/doctor-patient-lists/amda/ |archive-date = 13 September 2014 |df =  }}, which cites:
 * {{cite journal | vauthors = Teno JM, Gozalo PL, Mitchell SL, Kuo S, Rhodes RL, Bynum JP, Mor V | title = Does feeding tube insertion and its timing improve survival? | journal = Journal of the American Geriatrics Society | volume = 60 | issue = 10 | pages = 1918–21 | date = October 2012 | pmid = 23002947 | pmc = 3470758 | doi = 10.1111/j.1532-5415.2012.04148.x }}
-* {{cite journal | vauthors = Palecek EJ, Teno JM, Casarett DJ, Hanson LC, Rhodes RL, Mitchell SL | title = Comfort feeding only: a proposal to bring clarity to decision-making regarding difficulty with eating for persons with advanced dementia | journal = Journal of the American Geriatrics Society | volume = 58 | issue = 3 | pages = 580–4 | date = March 2010 | pmid = 20398123 | pmc = 2872797 | doi = 10.1111/j.1532-5415.2010.02740.x }}
+* {{cite journal | vauthors = Palecek EJ, Teno JM, Casarett DJ, Hanson LC, Rhodes RL, Mitchell SL | title = Comfort feeding only: a proposal to bring clarity to decision-making regarding difficulty with eating for persons with advanced dementia | journal = Journal of the American Geriatrics Society | volume = 58 | issue = 3 | pages = 580–84 | date = March 2010 | pmid = 20398123 | pmc = 2872797 | doi = 10.1111/j.1532-5415.2010.02740.x }}
-* {{cite journal | vauthors = Gillick MR, Volandes AE | title = The standard of caring: why do we still use feeding tubes in patients with advanced dementia? | journal = Journal of the American Medical Directors Association | volume = 9 | issue = 5 | pages = 364–7 | date = June 2008 | pmid = 18519120 | doi = 10.1016/j.jamda.2008.03.011 }}</ref><ref>{{cite journal | vauthors = Mitchell SL, Kiely DK, Lipsitz LA | title = The risk factors and impact on survival of feeding tube placement in nursing home residents with severe cognitive impairment | journal = Archives of Internal Medicine | volume = 157 | issue = 3 | pages = 327–32 | date = February 1997 | pmid = 9040301 | doi = 10.1001/archinte.1997.00440240091014 }}</ref>
+* {{cite journal | vauthors = Gillick MR, Volandes AE | title = The standard of caring: why do we still use feeding tubes in patients with advanced dementia? | journal = Journal of the American Medical Directors Association | volume = 9 | issue = 5 | pages = 364–67 | date = June 2008 | pmid = 18519120 | doi = 10.1016/j.jamda.2008.03.011 }}</ref><ref>{{cite journal | vauthors = Mitchell SL, Kiely DK, Lipsitz LA | title = The risk factors and impact on survival of feeding tube placement in nursing home residents with severe cognitive impairment | journal = Archives of Internal Medicine | volume = 157 | issue = 3 | pages = 327–32 | date = February 1997 | pmid = 9040301 | doi = 10.1001/archinte.1997.00440240091014 }}</ref>
 Benefits of this procedure in those with advanced dementia has not been shown.<ref>{{cite journal | vauthors = Sampson EL, Candy B, Jones L | title = Enteral tube feeding for older people with advanced dementia | journal = The Cochrane Database of Systematic Reviews | issue = 2 | pages = CD007209 | date = April 2009 | pmid = 19370678 | doi = 10.1002/14651858.CD007209.pub2 }}</ref> The risks of using tube feeding include agitation, the person pulling out the tube or otherwise being physically or chemically immobilized to prevent them from doing this, or getting [[pressure ulcers]].<ref name="AGSantipsychotic"/> There is about a 1% fatality rate directly related to the procedure<ref>{{cite journal | vauthors = Lockett MA, Templeton ML, Byrne TK, Norcross ED | title = Percutaneous endoscopic gastrostomy complications in a tertiary-care center | journal = The American Surgeon | volume = 68 | issue = 2 | pages = 117–20 | date = February 2002 | pmid = 11842953 }}</ref> with a 3% major complication rate.<ref>{{cite journal | vauthors = Finocchiaro C, Galletti R, Rovera G, Ferrari A, Todros L, Vuolo A, Balzola F | title = Percutaneous endoscopic gastrostomy: a long-term follow-up | journal = Nutrition | volume = 13 | issue = 6 | pages = 520–3 | date = June 1997 | pmid = 9263232 | doi = 10.1016/S0899-9007(97)00030-0 }}</ref> The percentage of people at the end of their life with dementia using feeding tubes in the USA has dropped from 12% in 2000 to 6% as of 2014.<ref>{{cite journal | vauthors = Mitchell SL, Mor V, Gozalo PL, Servadio JL, Teno JM | title = Tube Feeding in US Nursing Home Residents With Advanced Dementia, 2000-2014 | journal = JAMA | volume = 316 | issue = 7 | pages = 769–70 | date = August 2016 | pmid = 27533163 | pmc = 4991625 | doi = 10.1001/jama.2016.9374 | url = http://jama.jamanetwork.com/data/journals/jama/935644/jld160020.pdf | deadurl = no | archiveurl = https://web.archive.org/web/20170921235656/http://jama.jamanetwork.com/data/journals/jama/935644/jld160020.pdf | archivedate = 2017-09-21 | df =  }}</ref><ref name="NYT20160816">{{Cite news | url = https://www.nytimes.com/2016/08/30/health/tube-feeding-dementia-patients.html?_r=0 | title = The Decline of Tube Feeding for Dementia Patients | date = 29 August 2016 | work = New York Times | last1 = Span | first1 = Paula | name-list-format = vanc | access-date = 31 August 2016 | deadurl = no | archiveurl = https://web.archive.org/web/20160903051930/http://www.nytimes.com/2016/08/30/health/tube-feeding-dementia-patients.html?_r=0 | archivedate = 3 September 2016 | df =  }}</ref>
@@ Line 293: / Line 293: @@
 === Palliative care ===
-Given the progressive and terminal nature of dementia, [[palliative care]] can be helpful to patients and their caregivers by helping both people with the disorder and their caregivers understand what to expect, deal with loss of physical and mental abilities, plan out a patient's wishes and goals including surrogate decision making, and discuss wishes for or against [[CPR]] and [[life support]].<ref name="pmid15945590">{{cite journal | vauthors = Sampson EL, Ritchie CW, Lai R, Raven PW, Blanchard MR | title = A systematic review of the scientific evidence for the efficacy of a palliative care approach in advanced dementia | journal = International Psychogeriatrics | volume = 17 | issue = 1 | pages = 31–40 | date = March 2005 | pmid = 15945590 | pmc =  | doi =  | url = https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15945590 }}</ref><ref name="pmid24997202">{{cite journal | vauthors = Van den Block L | title = The need for integrating palliative care in ageing and dementia policies | journal = European Journal of Public Health | volume = 24 | issue = 5 | pages = 705–6 | date = October 2014 | pmid = 24997202 | pmc =  | doi = 10.1093/eurpub/cku084 | url = https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24997202 }}</ref> Because the decline can be rapid, and because most people prefer to allow the person with dementia to make their own decisions, palliative care involvement before the late stages of dementia is recommended.<ref>{{cite web|url=http://pmj.sagepub.com/content/early/2013/07/05/0269216313493685.full.pdf+html|title=White paper defining optimal palliative care in older people with dementia: A Delphi study and recommendations from the European         Association for Palliative Care|publisher=}}</ref><ref name="pmid18416791">{{cite journal | vauthors = Birch D, Draper J | title = A critical literature review exploring the challenges of delivering effective palliative care to older people with dementia | journal = Journal of Clinical Nursing | volume = 17 | issue = 9 | pages = 1144–63 | date = May 2008 | pmid = 18416791 | pmc =  | doi = 10.1111/j.1365-2702.2007.02220.x | url = https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18416791 }}</ref> Further research is required to determine the appropriate palliative care interventions and how well they help people with advanced dementia.<ref>{{cite journal | vauthors = Murphy E, Froggatt K, Connolly S, O'Shea E, Sampson EL, Casey D, Devane D | title = Palliative care interventions in advanced dementia | journal = The Cochrane Database of Systematic Reviews | volume = 12 | pages = CD011513 | date = December 2016 | pmid = 27911489 | doi = 10.1002/14651858.CD011513.pub2 | url = http://discovery.ucl.ac.uk/1532757/ }}</ref>
+Given the progressive and terminal nature of dementia, [[palliative care]] can be helpful to patients and their caregivers by helping both people with the disorder and their caregivers understand what to expect, deal with loss of physical and mental abilities, plan out a patient's wishes and goals including surrogate decision making, and discuss wishes for or against [[CPR]] and [[life support]].<ref name="pmid15945590">{{cite journal | vauthors = Sampson EL, Ritchie CW, Lai R, Raven PW, Blanchard MR | title = A systematic review of the scientific evidence for the efficacy of a palliative care approach in advanced dementia | journal = International Psychogeriatrics | volume = 17 | issue = 1 | pages = 31–40 | date = March 2005 | pmid = 15945590 | pmc =  | doi =  | url = https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15945590 }}</ref><ref name="pmid24997202">{{cite journal | vauthors = Van den Block L | title = The need for integrating palliative care in ageing and dementia policies | journal = European Journal of Public Health | volume = 24 | issue = 5 | pages = 705–06 | date = October 2014 | pmid = 24997202 | pmc =  | doi = 10.1093/eurpub/cku084 | url = https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24997202 }}</ref> Because the decline can be rapid, and because most people prefer to allow the person with dementia to make their own decisions, palliative care involvement before the late stages of dementia is recommended.<ref>{{cite web|url=http://pmj.sagepub.com/content/early/2013/07/05/0269216313493685.full.pdf+html|title=White paper defining optimal palliative care in older people with dementia: A Delphi study and recommendations from the European Association for Palliative Care|publisher=}}</ref><ref name="pmid18416791">{{cite journal | vauthors = Birch D, Draper J | title = A critical literature review exploring the challenges of delivering effective palliative care to older people with dementia | journal = Journal of Clinical Nursing | volume = 17 | issue = 9 | pages = 1144–63 | date = May 2008 | pmid = 18416791 | pmc =  | doi = 10.1111/j.1365-2702.2007.02220.x | url = https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18416791 }}</ref> Further research is required to determine the appropriate palliative care interventions and how well they help people with advanced dementia.<ref>{{cite journal | vauthors = Murphy E, Froggatt K, Connolly S, O'Shea E, Sampson EL, Casey D, Devane D | title = Palliative care interventions in advanced dementia | journal = The Cochrane Database of Systematic Reviews | volume = 12 | pages = CD011513 | date = December 2016 | pmid = 27911489 | doi = 10.1002/14651858.CD011513.pub2 | url = http://discovery.ucl.ac.uk/1532757/ }}</ref>
 [[Person-centered care]] helps maintain the dignity of people with dementia.<ref name="MitchellAgnelli2015">{{cite journal | vauthors = Mitchell G, Agnelli J | title = Person-centred care for people with dementia: Kitwood reconsidered | journal = Nursing Standard | volume = 30 | issue = 7 | pages = 46–50 | date = October 2015 | pmid = 26463810 | doi = 10.7748/ns.30.7.46.s47 }}</ref>
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 The number of cases of dementia worldwide in 2010 was estimated at 35.6 million.<ref name = "Prince_2012">{{cite journal|journal=Alzheimer's Disease International | title = World Alzheimer Report 2009 | year = 2009 | pages = 38 | url = http://www.alz.co.uk/research/world-report | access-date = 11 March 2012 | vauthors = Prince M, Jackson J | deadurl = no | archive-url = https://web.archive.org/web/20120311215443/http://www.alz.co.uk/research/world-report | archive-date = 11 March 2012 }}</ref> In 2015, 46.8 million people live with dementia, with 58% living in low and middle income countries.<ref name=":0">{{Cite web|url=https://www.alz.co.uk/research/WorldAlzheimerReport2015.pdf|title=World Alzheimer Report 2015|last=Alzheimer's Disease International|date=Sep 2015|website=|archive-url=|archive-date=|dead-url=|access-date=30 October 2018}}</ref> The prevalence of dementia differs in different world regions, ranging from 4.7% in Central Europe to 8.7% in North Africa/Middle East; the prevalence in other regions is estimated to be between 5.6 and 7.6% .<ref name=":0" />  The number of people living with dementia is estimated to double every 20 years. In 2013 dementia resulted in about 1.7 million deaths, up from 0.8 million in 1990.<ref name="GDB2013" /> Around two thirds of individuals with dementia live in low- and middle-income countries, where the sharpest increases in numbers are predicted.<ref name = "Prince_2012" />
-The annual incidence of dementia is over 9.9 million worldwide. Almost half of the new cases of dementia occur in Asia, followed by Europe (25%), the Americas (18%) and Africa (8%). The incidence of dementia increases exponentially with increase in age, doubling with every 6.3 year increase in age.<ref name=":0" /> Dementia affecting 5% of the population older than 65 and 20–40% of those older than 85.<ref name="Sadock2008">{{cite book|title=Kaplan & Sadock's concise textbook of clinical psychiatry|last1=Sadock|first1=Benjamin J.|last2=Sadock|first2=Virginia A.|publisher=Wolters Kluwer/Lippincott Williams & Wilkins|year=2008|isbn=978-0-7817-8746-8|edition=3rd|location=Philadelphia|page=52|chapter=Delirium, Dementia, and Amnestic and Other Cobnitive Disorders and Mental Disorders Due to a General Medical Condition|name-list-format=vanc|chapter-url=https://books.google.com/books?id=ubG51n2NgfwC&pg=PA52}}</ref> Rates are slightly higher in women than men at ages 65 and greater.<ref name="Sadock2008" />
+The annual incidence of dementia is over 9.9 million worldwide. Almost half of the new cases of dementia occur in Asia, followed by Europe (25%), the Americas (18%) and Africa (8%). The incidence of dementia increases exponentially with increase in age, doubling with every 6.3 year increase in age.<ref name=":0" /> Dementia affecting 5% of the population older than 65 and 20–40% of those older than 85.<ref name="Sadock2008">{{cite book|title=Kaplan & Sadock's concise textbook of clinical psychiatry|last1=Sadock|first1=Benjamin J.|last2=Sadock|first2=Virginia A.|publisher=Wolters Kluwer/Lippincott Williams & Wilkins|year=2008|isbn=978-0781787468|edition=3rd|location=Philadelphia|page=52|chapter=Delirium, Dementia, and Amnestic and Other Cobnitive Disorders and Mental Disorders Due to a General Medical Condition|name-list-format=vanc|chapter-url=https://books.google.com/books?id=ubG51n2NgfwC&pg=PA52}}</ref> Rates are slightly higher in women than men at ages 65 and greater.<ref name="Sadock2008" />
 Dementia impacts not only the individuals with dementia, but also their carers and the wider society. Among people aged 60 years and over, dementia is ranked the 9th most burdensome condition according to the 2010 Global Burden of Disease (GBD) estimates.The global costs of dementia is around US$818 billion in 2015, a 35.4% increase from US$604 billion in 2010.<ref name=":0" />
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 Until the end of the 19th century, dementia was a much broader clinical concept. It included mental illness and any type of psychosocial incapacity, including conditions that could be reversed.<ref name=Berr>{{cite journal | vauthors = Berrios GE | title = Dementia during the seventeenth and eighteenth centuries: a conceptual history | journal = Psychological Medicine | volume = 17 | issue = 4 | pages = 829–37 | date = November 1987 | pmid = 3324141 | doi = 10.1017/S0033291700000623 }}</ref> ''Dementia'' at this time simply referred to anyone who had lost the ability to reason, and was applied equally to psychosis of mental illness, "organic" diseases like [[syphilis]] that destroy the brain, and to the dementia associated with old age, which was attributed to "hardening of the arteries".
-Dementia has been referred to in medical texts since antiquity. One of the earliest known allusions to dementia is attributed to the 7th-century BC [[Ancient Greek philosophy|Greek philosopher]] [[Pythagoras]], who divided the human lifespan into six distinct phases, which were 0–6 (infancy), 7–21 (adolescence), 22–49 (young adulthood), 50–62 (middle age), 63–79 (old age), and 80–death (advanced age). The last two he described as the "senium", a period of mental and physical decay, and of the final phase being where "the scene of mortal existence closes after a great length of time that very fortunately, few of the human species arrive at, where the mind is reduced to the imbecility of the first epoch of infancy".<ref>Berchtold, N.C. and Cotman, C.W. (1998) Evolution in the conceptu-alization of dementia and Alzheimer's disease: Greco-Roman period to the 1960s. Neurobiol Aging 19, 173–189</ref> In 550&nbsp;BC, the Greek Athenian statesman and poet [[Solon]] argued that the terms of a man's will might be invalidated if he exhibited loss of judgement due to advanced age. Chinese medical texts made allusions to the condition as well, and the characters for "dementia" translate literally to "foolish old person".{{Citation needed|date=February 2017}}
+Dementia has been referred to in medical texts since antiquity. One of the earliest known allusions to dementia is attributed to the 7th-century BC [[Ancient Greek philosophy|Greek philosopher]] [[Pythagoras]], who divided the human lifespan into six distinct phases, which were 0–6 (infancy), 7–21 (adolescence), 22–49 (young adulthood), 50–62 (middle age), 63–79 (old age), and 80–death (advanced age). The last two he described as the "senium", a period of mental and physical decay, and of the final phase being where "the scene of mortal existence closes after a great length of time that very fortunately, few of the human species arrive at, where the mind is reduced to the imbecility of the first epoch of infancy".<ref>Berchtold, N.C. and Cotman, C.W. (1998) Evolution in the conceptu-alization of dementia and Alzheimer's disease: Greco-Roman period to the 1960s. Neurobiol Aging 19, 173–89</ref> In 550&nbsp;BC, the Greek Athenian statesman and poet [[Solon]] argued that the terms of a man's will might be invalidated if he exhibited loss of judgement due to advanced age. Chinese medical texts made allusions to the condition as well, and the characters for "dementia" translate literally to "foolish old person".{{Citation needed|date=February 2017}}
 [[Aristotle]] and [[Plato]] from Ancient  Greece spoke of the mental decay of advanced age, but apparently simply viewed it as an inevitable process that affected all old men, and which nothing could prevent. Plato stated that the elderly were unsuited for any position of responsibility because, "There is not much acumen of the mind that once carried them in their youth, those characteristics one would call judgement, imagination, power of reasoning, and memory. They see them gradually blunted by deterioration and can hardly fulfill their function."{{Citation needed|date=February 2017}}
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 By the period of 1913–20, [[schizophrenia]] had been well-defined in a way similar to today, and also the term ''[[dementia praecox]]'' had been used to suggest the development of senile-type dementia at a younger age. Eventually the two terms fused, so that until 1952 physicians used the terms ''dementia praecox'' (precocious dementia) and ''schizophrenia'' interchangeably. The term ''precocious dementia'' for a mental illness suggested that a type of mental illness like schizophrenia (including paranoia and decreased cognitive capacity) could be expected to arrive normally in all persons with greater age (see [[paraphrenia]]). After about 1920, the beginning use of ''dementia''  for what is now understood as schizophrenia and senile dementia helped limit the word's meaning to "permanent, irreversible mental deterioration". This began the change to the more recognizable use of the term today.
-In 1976, neurologist Robert Katzmann suggested a link between senile dementia and Alzheimer's disease.<ref>{{cite news |first=Gina |last=Kolata | name-list-format = vanc |authorlink=Gina Kolata |title=Drug Trials Test Bold Plan to Slow Alzheimer's |url=https://www.nytimes.com/2010/07/17/health/research/17drug.html |newspaper=The New York Times |date=June 17, 2010 |access-date=June 17, 2010 |deadurl=no |archive-url=https://web.archive.org/web/20120409121141/http://www.nytimes.com/2010/07/17/health/research/17drug.html |archive-date=April 9, 2012 |df= }}</ref> Katzmann suggested that much of the senile dementia occurring (by definition) after the age of 65, was pathologically identical with Alzheimer's disease occurring before age 65 and therefore should not be treated differently. He noted that "senile dementia" not being considered a disease, but rather part of aging, was keeping millions of aged patients experiencing what otherwise was identical with Alzheimer's disease from being diagnosed as having a disease process, rather than simply considered as aging normally.<ref name="Katzman1976">{{cite journal | vauthors = Katzman R | title = Editorial: The prevalence and malignancy of Alzheimer disease. A major killer | journal = Archives of Neurology | volume = 33 | issue = 4 | pages = 217–8 | date = April 1976 | pmid = 1259639 | doi = 10.1001/archneur.1976.00500040001001 }}</ref> Katzmann thus suggested that Alzheimer's disease, if taken to occur over age 65, is actually common, not rare, and was the fourth- or 5th-leading cause of death, even though rarely reported on death certificates in 1976.
+In 1976, neurologist Robert Katzmann suggested a link between senile dementia and Alzheimer's disease.<ref>{{cite news |first=Gina |last=Kolata | name-list-format = vanc |authorlink=Gina Kolata |title=Drug Trials Test Bold Plan to Slow Alzheimer's |url=https://www.nytimes.com/2010/07/17/health/research/17drug.html |newspaper=The New York Times |date=June 17, 2010 |access-date=June 17, 2010 |deadurl=no |archive-url=https://web.archive.org/web/20120409121141/http://www.nytimes.com/2010/07/17/health/research/17drug.html |archive-date=April 9, 2012 |df= }}</ref> Katzmann suggested that much of the senile dementia occurring (by definition) after the age of 65, was pathologically identical with Alzheimer's disease occurring before age 65 and therefore should not be treated differently. He noted that "senile dementia" not being considered a disease, but rather part of aging, was keeping millions of aged patients experiencing what otherwise was identical with Alzheimer's disease from being diagnosed as having a disease process, rather than simply considered as aging normally.<ref name="Katzman1976">{{cite journal | vauthors = Katzman R | title = Editorial: The prevalence and malignancy of Alzheimer disease. A major killer | journal = Archives of Neurology | volume = 33 | issue = 4 | pages = 217–18 | date = April 1976 | pmid = 1259639 | doi = 10.1001/archneur.1976.00500040001001 }}</ref> Katzmann thus suggested that Alzheimer's disease, if taken to occur over age 65, is actually common, not rare, and was the fourth- or 5th-leading cause of death, even though rarely reported on death certificates in 1976.
 This suggestion opened the view that dementia is never normal, and must always be the result of a particular disease process, and is not part of the normal healthy aging process, ''per se''. The ensuing debate led for a time to the proposed disease diagnosis of "senile dementia of the Alzheimer's type" (SDAT) in persons over the age of 65, with "Alzheimer's disease" diagnosed in persons younger than 65 who had the same pathology. Eventually, however, it was agreed that the age limit was artificial, and that ''Alzheimer's disease'' was the appropriate term for persons with the particular brain pathology seen in this disorder, regardless of the age of the person with the diagnosis. A helpful finding was that although the incidence of Alzheimer's disease increased with age (from 5–10% of 75-year-olds to as many as 40–50% of 90-year-olds), there was no age at which all persons developed it, so it was not an inevitable consequence of aging, no matter how great an age a person attained. Evidence of this is shown by numerous documented supercentenarians (people living to 110 or more) that experienced no serious cognitive impairment. There is some evidence that dementia is most likely to develop between the ages of 80 and 84 and individuals who pass that point without being affected have a lower chance of developing it. Women account for a larger percentage of dementia cases than men, although this can be attributed to their longer overall lifespan and greater odds of attaining an age where the condition is likely to occur.{{Citation needed|date=February 2017}}
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 Also, after 1952, mental illnesses like schizophrenia were removed from the category of ''[[organic brain syndrome]]s'', and thus (by definition) removed from possible causes of "dementing illnesses" (dementias). At the same, however, the traditional cause of senile dementia – "hardening of the arteries" – now returned as a set of dementias of vascular cause (small strokes). These were now termed ''multi-infarct dementias'' or ''[[vascular dementia]]s''.
-In the 21st century, a number of other types of dementia have been differentiated from Alzheimer's disease and vascular dementias (these two being the most common types). This differentiation is on the basis of pathological examination of brain tissues, by symptomatology, and by different patterns of brain metabolic activity in nuclear medical imaging tests such as [[SPECT]] and [[Positron emission tomography|PET]]scans of the brain. The various forms of dementia have differing prognoses (expected outcome of illness), and also differing sets of epidemiologic risk factors. The causal etiology of many of them, including Alzheimer's disease, remains unclear, although many theories exist such as accumulation of protein plaques as part of normal aging, inflammation (either from bacterial pathogens or exposure to toxic chemicals), inadequate blood sugar, and traumatic brain injury.{{Citation needed|date=February 2017}}
+In the 21st century, a number of other types of dementia have been differentiated from Alzheimer's disease and vascular dementias (these two being the most common types). This differentiation is on the basis of pathological examination of brain tissues, by symptomatology, and by different patterns of brain metabolic activity in nuclear medical imaging tests such as [[SPECT]] and [[Positron emission tomography|PETscans]] of the brain. The various forms of dementia have differing prognoses (expected outcome of illness), and also differing sets of epidemiologic risk factors. The causal etiology of many of them, including Alzheimer's disease, remains unclear, although many theories exist such as accumulation of protein plaques as part of normal aging, inflammation (either from bacterial pathogens or exposure to toxic chemicals), inadequate blood sugar, and traumatic brain injury.{{Citation needed|date=February 2017}}
 ==Society and culture==
@@ Line 355: / Line 355: @@
 [[Driving]] with dementia could lead to severe injury or even death to self and others. Doctors should advise appropriate testing on when to quit driving.<ref>{{cite web |title=Drivers with dementia a growing problem, MDs warn |date=September 19, 2007 |publisher=CBC News, Canada |url=http://www.cbc.ca/health/story/2007/09/19/drivers-dementia.html?ref=rss |deadurl=no |archive-url=https://web.archive.org/web/20071002100058/http://www.cbc.ca/health/story/2007/09/19/drivers-dementia.html?ref=rss |archive-date=October 2, 2007 |df= }}</ref> The United Kingdom [[DVLA]] (Driver & Vehicle Licensing Agency) states that people with dementia who specifically have poor short term memory, disorientation, or lack of insight or judgment are not fit to drive, and in these instances the DVLA must be informed so that the driving licence can be revoked. They do, however, acknowledge low-severity cases and those with an early diagnosis, and those drivers may be permitted to drive pending medical reports.
 Many support networks are available to people with dementia and their families and caregivers. Several charitable organisations aim to raise awareness and campaign for the rights of people living with dementia. There is also support and guidance on assessing testamentary capacity in people who have dementia.<ref>{{cite journal | vauthors = Thompson SB | year = 2009 | title = Testamentary capacity and cognitive rehabilitation: implications for head-injured and neurologically impaired individuals | url = | journal = Journal of Cognitive Rehabilitation | volume = 27 | issue = | pages = 11–13 }}</ref>
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 == Dental health ==
-There is limited evidence that links poor oral health to cognitive decline. However, failure to perform tooth brushing and gingival inflammation can be used as dementia risk predictors.<ref>{{cite journal | vauthors = Daly B, Thompsell A, Sharpling J, Rooney YM, Hillman L, Wanyonyi KL, White S, Gallagher JE | title = Evidence summary: the relationship between oral health and dementia | journal = British Dental Journal | volume = 223 | issue = 11 | pages = 846–853 | date = January 2018 | pmid = 29192686 | doi = 10.1038/sj.bdj.2017.992 | url = https://www.nature.com/articles/sj.bdj.2017.992 | deadurl = no | archiveurl = https://web.archive.org/web/20180509175543/https://www.nature.com/articles/sj.bdj.2017.992 | archivedate = 2018-05-09 | df =  }}</ref>
+There is limited evidence that links poor oral health to cognitive decline. However, failure to perform tooth brushing and gingival inflammation can be used as dementia risk predictors.<ref>{{cite journal | vauthors = Daly B, Thompsell A, Sharpling J, Rooney YM, Hillman L, Wanyonyi KL, White S, Gallagher JE | title = Evidence summary: the relationship between oral health and dementia | journal = British Dental Journal | volume = 223 | issue = 11 | pages = 846–53 | date = January 2018 | pmid = 29192686 | doi = 10.1038/sj.bdj.2017.992 | url = https://www.nature.com/articles/sj.bdj.2017.992 | deadurl = no | archiveurl = https://web.archive.org/web/20180509175543/https://www.nature.com/articles/sj.bdj.2017.992 | archivedate = 2018-05-09 | df =  }}</ref>
 === Oral bacteria ===
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 == External links ==
 {{Medical condition classification and resources
 | ICD10           = {{ICD10|F|00||f|00}}-{{ICD10|F|07||f|00}}
 | ICD9            = {{ICD9|290}}-{{ICD9|294}}

Classification	D ICD-10: F00-F07 ICD-9-CM: 290-294 MeSH: D003704 DiseasesDB: 29283
External resources	MedlinePlus: 000739 eMedicine: article/793247 Patient UK: Dementia

Authority control databases
International	FAST
National	Spain France BnF data Germany Israel United States Japan Czech Republic